Birthcohort | Birthcohorts

Cohort, name
The Prospective Epidemiological Research Studies in Iran Birth Cohort

Cohort, abbreviation
PERSIAN Birth Cohort

Cohort, country
Iran (ایران)

Cohort, website
http://persian-bc.cfamily

Key reference
Prevention, Epigenetic, Neurodevelopment, Environmental Exposure, Growth

Date of filling in this questionnaire:
2018-12-11
Principal investigator(s), name
Professor. Roya Kelishadi

Principal investigator(s), e-mail address
roya.kelishadi@gmail.com

Principal investigator(s), institution
Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfah

Contact person(s), name
Prof. Roya Kelishadi

Contact person(s), e-mail address
roya.kelishadi@gmail.com

Contact person(s), institution address
Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non Communicable Disease, Isfahan University of Medical Sciences, Hezar Jerib Ave, Isfahan, Iran

Main aim of cohort
The overarching aim of this project is to study the factors related to the Developmental Origins of Health and Diseases (DOHaD) in Iranian population. Towards this aim, we will evaluate the impact of socioenvironmental, psychological and genetic factors on pregnancy outcomes, child mental and physical health, growth, and development, and early- and late-onset chronic non-communicable diseases.

Recruited number of:
15000 children / 15000 mothers / 15000 fathers / 0 grand parents / 0 other family members

Approximate proportion of source population included
10

Source population
Nation-based
Period of enrollment
Start: 2016-01-01, End: 2019-03-20

Enrollment period
Pregnancy, week 0 to 12

Enrollment criteria, please specify
We enroll pregnant women with Iranian nationality, reside in the catchment area of the study center, plan to give birth in the hospitals located in the city where the cohort is undergoing, natural pregnancy or with history of using assisted reproductive techniques for treating infertility, and do not have any communication problems. Pregnancies ending in both natural vaginal delivery and Cesarean section are included in the study.

Exclusion criteria, please specify
Those women who would migrate from the city of the ongoing cohort, Give birth in not a reference hospital, and those without compliance to follow the study will be excluded from the study.

Planned age of children at end of follow-up
10 years

Questionnaire or registry data and biological samples

General information	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Home address	X
School address								X

Birth outcomes
Birth weight	X
Birth length	X
Gestational age at birth	X
Apgar score	X
Congenital malformations	X
Stillbirth (>= 22 weeks)	X
Child’s sex	X
Head circumference	X
Biparietal diameter	X

Child exposures	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Breast feeding	X	X	X
Diet	X	X	X	X	X	X	X	X	X	X	X
Dietary supplements	X	X	X	X	X	X	X	X	X	X	X
Childcare attendance	X	X	X	X	X	X	X
Active smoking											X
Passive smoking	X	X	X	X	X	X	X	X	X	X	X
Alcohol consumption
Physical activity		X	X	X	X	X	X	X	X	X
Substance use
Medicine intake	X	X	X	X	X	X	X	X	X	X
Vaccinations	X	X	X				X
Psychological distress (e.g. bullying)						X	X	X	X	X	X
Air pollution	X	X	X	X	X	X	X	X	X	X	X
Access to green spaces	X	X	X	X	X	X	X	X	X	X	X
Built environment	X	X	X	X	X	X	X	X	X	X	X
Noise	X	X	X	X	X	X	X	X	X	X	X
Radiation, electromagnetic fields	X	X	X	X	X	X	X	X	X	X	X
Water contamination	X	X	X	X	X	X	X	X	X	X	X
Pets	X	X	X	X	X	X	X	X	X	X	X
Farm animal exposure	X	X	X	X	X	X	X	X	X	X	X
Biomarkers of exposure
Mercury	X		X
Lead
Cadmium
Arsenic	X		X
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens	X
Benzophenones
Triclosan
Phthalates	X			X
Cotinine

Child development and health	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Anthropometry
Weight	X	X	X	X	X	X	X	X	X	X	X
Height	X	X	X	X	X	X	X	X	X	X	X
Head circumference	X	X	X	X
Abdominal circumference	X		X		X	X	X	X	X	X	X
Arm circumference	X		X	X	X	X	X	X	X	X	X
Wrist circumference	X
Waist circumference	X		X		X	X	X	X	X	X	X
Clinical examinations
Blood pressure		X	X	X	X	X	X	X	X	X	X
Carotida intima media thickness
Pulse wave velocity
Cardiac ultrasound
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan results
Skin folds
Bio impedence
Oscilometry
Spirometry
Skin prick test
Bronchial challenge test
Reversibility test
Dental observations			X			X					X
Mental and neurological development
Cognitive function	X
School performance
Language		X	X
ADHD				X
Autism			X	X
Sleep disturbances	X		X
Mental health				X	X	X	X	X	X	X	X
Respiratory health
Asthma	X	X	X
Allergy	X	X	X
Allergic rhinitis	X	X	X
Eczema	X	X	X
Respiratory tract infections	X	X	X
Senses
Vision	X		X	X			X				X
Hearing	X		X				X				X
Musculo-skeletal health
Back pain
Neck pain
Growing pains			X	X	X	X
Sexual maturation
Tanner stage							X	X	X	X	X
Pubertal development stage							X	X	X	X	X
Age at menarche								X	X	X	X
Age at voice change										X	X
2D/4D digit ratio
Nocturnal ejaculation											X
Acne											X
Other health outcomes
Cancer		X	X	X	X	X	X	X	X	X	X
Diabetes			X	X	X	X	X	X	X	X	X
Congenital anomalies	X	X
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones	X
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients						X
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)				X							X
Metabolomics
DNA methylation	X
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Child biological samples	---------- Child age (years) at sampling ----------
	At birth	0	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Whole blood
Serum
Plasma
Buffy coat	X
Urine		X		X
Hair		X		X
Teeth							X	X
Nails		X
Saliva
Purified DNA
Purified RNA
Red blood cells
Umbilical cord blood/tissue	X
Blood smear
Faeces/meconium		X		X
Exhaled breathe condensate
Sputum induction
Placenta

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education	X	X
Income	X	X
Employment status	X	X	X		X
Job title	X	X	X		X
Single parenthood	X	X	X	X	X
Home address	X	X	X	X	X
Work address	X	X

Maternal characteristics related to the index pregnancy/child
Age at birth	X
Ethnicity	X
Country of birth	X
Planned pregnancy	X
Time to pregnancy	X
Fertility treatment	X
Prior spontaneous abortion (<22w)	X
Prior births	X
Ultrasound measurements	X
Doppler measurements
Preeclampsia	X
Gestational diabetes	X
Gestational hypertension	X
Gestational duration	X
Mode of delivery	X
Prenatal diagnostics	X
Medical termination of pregnancy	X

Maternal Exposures	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Diet	X	X	X	X
Dietary supplements	X	X	X	X
Active smoking		X	X	X
Passive smoking		X	X	X	X
Alcohol consumption		X	X	X
Physical activity		X	X	X
Substance use		X	X	X
Medicine intake	X	X	X	X
Coffee drinking	X	X	X	X
Psychological distress (e.g. life-events, health behaviors, perceived stress)	X
Occupational exposures	X	X	X	X
Heavy lifts		X	X	X
Work hours	X	X	X	X
Air pollution		X	X	X
Access to green spaces		X	X	X
Built environment	X	X	X	X
Noise		X	X	X
Radiation, electromagnetic fields		X	X	X
Water contamination		X	X	X
Binge drinking		X	X	X
Pets	X	X			X
Farm animal exposure	X				X
Biomarkers of exposure
Mercury		X	X	X
Lead
Cadmium		X
Arsenic		X	X	X
Other metals
Polychlorinated biphenyl esters		X	X	X
Dicloro difenil tricloroetano		X	X	X
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A		X
Other bisphenols
Parabens		X
Benzophenones
Triclosan
Phthalates		X	X	X
Cotinine

Maternal health	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Anthropometry
Weight	X	X	X	X
Height	X	X	X	X
Waist circumference	X	X	X	X
Clinical examinations
Blood pressure	X	X	X	X
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence
Mental and neurological development
Mental health				X
Cognitive function (e.g. intelligence quotient)				X
Respiratory health
Asthma	X	X	X	X
Allergy	X	X	X	X
Musculo‐skeletal disease
Back pain	X	X	X	X
Neck pain	X	X	X	X
Arthritis	X	X	X	X
Other health outcomes
Cancer	X	X	X	X
Diabetes	X	X	X	X
Cardio‐vascular disease	X	X	X	X
Family history of chronic disease	X	X	X	X
Infectious disease	X	X	X	X
Fever	X	X	X	X
Autoimmune disease	X	X	X	X
Urinary symptoms	X	X	X	X
Sexual problems	X	X	X	X
Sleep disturbance	X	X	X	X
Biomarkers of health
Nephrology (e.g. creatinine, albumin)	X
Thyroid hormones	X
Inflammatory markers (e.g. C-reactive protein cytokines)	X
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients	X
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)	X
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Maternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Breast milk					X
Whole blood
Serum		X	X	X
Plasma
Buffy coat
Urine		X	X	X
Hair		X	X	X
Nails		X	X	X
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education	X
Income	X
Employment status	X
Job title	X
Single parenthood	X
Home address	X
Work address	X

Paternal characteristics related to the index pregnancy/child
Fertility treatment	X
Age at child's birth	X
Ethnicity	X
Country of birth	X

Paternal exposures	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Diet	X
Dietary supplements	X
Active smoking	X
Passive smoking	X
Alcohol consumption
Physical activity
Substance use	X
Medicine intake	X
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures
Heavy lifts
Work hours	X
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields	X
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Paternal health	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Anthropometry
Weight	X
Height	X
Waist circumference	X
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental health	X
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma	X
Allergy	X
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer	X
Diabetes	X
Cardio‐vascular disease	X
Family history of chronic disease	X
Infectious disease	X
Fever	X
Autoimmune disease	X
Urinary symptoms	X
Sexual problems	X
Sleep disturbance	X
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Paternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Semen
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces

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