Birthcohort | Birthcohorts

Cohort, name
Odense Child Cohort

Cohort, abbreviation

Cohort, country
Denmark (Danmark)

Cohort, website
http://www.odense.dk/odensekohorten

Cohort, facebook-site
OUH - Odense Børnekohorte

Date of filling in this questionnaire:
2022-01-05
Principal investigator(s), name
Henriette Boye

Principal investigator(s), e-mail address
henriette.boye@rsyd.dk

Principal investigator(s), institution
Odense University Hospital, Hans Christian Andersen Children's Hospital, Paediatric Research Unit

Contact person(s), name
Henriette Boye

Contact person(s), e-mail address
Henriette.boye@rsyd.dk

Contact person(s), institution address
Odense University Hospital, Hans Christian Andersen Children's Hospital, Paediatric Research Unit

Main aim of cohort
The overall aim of the project is to obtain information on the interaction between the fetus/infant/child during pregnancy, birth and childhood and the social and environmental determinants for health and disease.

Recruited number of:
2553 children / 2874 mothers / 2693 fathers / 0 grand parents / 0 other family members

Approximate proportion of source population included
43

Source population
Other, please describeCity
Period of enrollment
Start: 2010-01-01, End: 2012-12-31

Enrollment period
Later, month 0 to 3

Enrollment criteria, please specify
Living in the municipality of Odense

Exclusion criteria, please specify
Moving from the municipality of Odense before birth

Planned age of children at end of follow-up
18 years

Questionnaire or registry data and biological samples

General information	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Home address								X		X			X
School address								X		X		X

Birth outcomes
Birth weight	X
Birth length	X
Gestational age at birth	X
Apgar score	X
Congenital malformations
Stillbirth (>= 22 weeks)	X
Child’s sex	X
Head circumference
Biparietal diameter

Child exposures	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Breast feeding	X	X
Diet	X	X		X		X		X		X			X
Dietary supplements						X		X		X			X
Childcare attendance				X
Active smoking													X
Passive smoking	X	X		X		X				X			X
Alcohol consumption													X
Physical activity	X	X		X		X		X		X			X
Substance use
Medicine intake	X	X		X		X		X		X			X
Vaccinations	X	X		X		X				X			X
Psychological distress (e.g. bullying)								X		X			X
Air pollution
Access to green spaces
Built environment				X		X
Noise
Radiation, electromagnetic fields
Water contamination
Pets		X		X		X
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds		X
Bisphenol A						X		X
Other bisphenols
Parabens
Benzophenones						X
Triclosan
Phthalates								X
Cotinine	X

Child development and health	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Anthropometry
Weight	X	X		X		X		X		X			X
Height	X	X		X		X		X		X			X
Head circumference	X	X		X		X
Abdominal circumference		X		X		X		X
Arm circumference
Wrist circumference				X
Waist circumference
Clinical examinations
Blood pressure	X	X		X		X		X		X			X
Carotida intima media thickness
Pulse wave velocity													X
Cardiac ultrasound
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan results								X		X			X
Skin folds	X	X		X		X		X		X			X
Bio impedence
Oscilometry
Spirometry
Skin prick test
Bronchial challenge test
Reversibility test
Dental observations					X			X
Mental and neurological development
Cognitive function								X
School performance								X
Language			X	X
ADHD						X
Autism						X
Sleep disturbances				X		X							X
Mental health				X		X		X					X
Respiratory health
Asthma		X		X		X				X			X
Allergy				X		X				X			X
Allergic rhinitis
Eczema				X		X				X			X
Respiratory tract infections				X		X
Senses
Vision								X		X
Hearing								X		X
Musculo-skeletal health
Back pain
Neck pain
Growing pains				X		X							X
Sexual maturation
Tanner stage										X
Pubertal development stage										X			X
Age at menarche													X
Age at voice change
2D/4D digit ratio
Nocturnal ejaculation
Acne
Other health outcomes
Cancer
Diabetes
Congenital anomalies
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol	X
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)	X	X		X
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Child biological samples	---------- Child age (years) at sampling ----------
	At birth	0	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Whole blood			X
Serum	X	X	X		X		X		X		X			X
Plasma	X	X	X		X		X		X		X			X
Buffy coat	X
Urine							X		X		X			X
Hair	X						X
Teeth							X	X
Nails
Saliva
Purified DNA	X	X
Purified RNA
Red blood cells
Umbilical cord blood/tissue	X
Blood smear
Faeces/meconium							X		X
Exhaled breathe condensate
Sputum induction
Placenta

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education		X						X
Income
Employment status
Job title
Single parenthood		X										X			X
Home address		X				X		X		X		X			X
Work address

Maternal characteristics related to the index pregnancy/child
Age at birth	X
Ethnicity	X
Country of birth
Planned pregnancy	X
Time to pregnancy	X
Fertility treatment	X
Prior spontaneous abortion (<22w)	X
Prior births	X
Ultrasound measurements
Doppler measurements
Preeclampsia
Gestational diabetes
Gestational hypertension
Gestational duration	X
Mode of delivery	X
Prenatal diagnostics	X
Medical termination of pregnancy	X

Maternal Exposures	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Diet		X		X	X
Dietary supplements		X		X	X
Active smoking		X		X	X
Passive smoking					X
Alcohol consumption		X		X	X
Physical activity		X		X	X
Substance use		X			X
Medicine intake		X		X	X
Coffee drinking		X		X	X
Psychological distress (e.g. life-events, health behaviors, perceived stress)		X		X	X
Occupational exposures					X
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination		X		X
Binge drinking		X		X
Pets					X
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A				X
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates		X
Cotinine

Maternal health	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Anthropometry
Weight		X		X	X
Height		X			X
Waist circumference
Clinical examinations
Blood pressure		X	X	X
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence
Mental and neurological development
Mental health				X	X
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer		X
Diabetes		X
Cardio‐vascular disease
Family history of chronic disease
Infectious disease
Fever
Autoimmune disease
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones				X
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol				X
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)				X
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Maternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Breast milk					X
Whole blood
Serum		X		X
Plasma
Buffy coat
Urine				X
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education								X
Income
Employment status
Job title
Single parenthood															X
Home address						X		X		X		X			X
Work address

Paternal characteristics related to the index pregnancy/child
Fertility treatment	X
Age at child's birth	X
Ethnicity	X
Country of birth

Paternal exposures	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Diet
Dietary supplements
Active smoking		X
Passive smoking
Alcohol consumption			X
Physical activity
Substance use
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Paternal health	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Anthropometry
Weight		X	X
Height		X	X
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer			X
Diabetes			X
Cardio‐vascular disease
Family history of chronic disease
Infectious disease
Fever
Autoimmune disease
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Paternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Semen
Whole blood
Serum		X
Plasma
Buffy coat
Urine
Hair		X
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces

Comments and ideas

Comments and ideas
We have around 20 subprojects. Here is a list of some of the projects: Exposure to endocrine disrupting chemicals Impact of hormonal and metabolic factors in pregnacy and neonatal health Prenatal exposure to ethanol and long-term effects Study on breastfeeding The role of vitamin D in pregnant and offspring Infections in early childhood Language development in Danish children Oral health in children Establishment of pediatric reference intervals Study of Preschool ADHD Risk Indicators Mothers health and child obesity Religion and health Exposure to pesticids. Effects on children Incidense of intestinal parasites in faeces Risk factors for Filaggrin Expression and Atopic Dermatitis Long-term health risk of excessive screen media use in children Neuropsychological development in schoolchildren