Identification

• Cohort, name
  Children (Barn), Allergy, Milieu, Stockholm, Epidemiological study
  
  Cohort, abbreviation
  BAMSE
  
  Cohort, country
  Sweden (Sverige)
  
  Cohort, website
  https://ki.se/en/imm/bamse-project
  
  Key reference
  Wickman M, Kull I, Pershagen G, Nordvall SL. The BAMSE Project: presentation of a prospective longitudinal birth cohort study. Pediatr Allergy Immunol 2002: 13 (Suppl. 15): 11–13.
  
  Date of filling in this questionnaire:
  2021-07-07
  
  
• Principal investigator(s), name
  Erik Melén
  
  Principal investigator(s), e-mail address
  erik.melen@ki.se
  
  Principal investigator(s), institution
  Karolinska Institutet, PO.Box 2010, 171 76 Stockholm, Sweden
  
  Contact person(s), name
  Anna Bergstrom
  
  Contact person(s), e-mail address
  Anna.Bergstrom@ki.se
  
  Contact person(s), institution address
  Karolinska Institutet, PO.Box 2010, 171 76 Stockholm, Sweden
  
  

Basic description

• Main aim of cohort
  The main aim of this Swedish population-based birth cohort is to study risk factors for asthma, allergic diseases and lung function and to study factors of importance for prognosis at already established disease. Main exposures: Allergens, nutrients/foods, air pollution, tobacco smoke, indoor environment, lifestyle, genetics Main outcomes: Asthma, eczema, allergic rhinitis, food allergy, lung function, dermatology, functional gastro intestinal disorders
  
  Recruited number of:
  4089 children / 4089 mothers / 4089 fathers / 0 grand parents / 0 other family members
  
  Approximate proportion of source population included
  75
  
  Source population
  Region-based
  
  
• Period of enrollment
  Start: 1994-00-00, End: 1996-00-00
  
  Enrollment period
  At birth  to
  
  Enrollment criteria, please specify
  All eligible children born during the enrolment period in the predefined areas of the central and north-western parts of Stockholm, representative for Sweden
  
  Exclusion criteria, please specify
  Insufficient knowledge in Swedish, planned to move within one year, child seriously ill
  
  Planned age of children at end of follow-up
  unrestricted years

Questionnaire or registry data and biological samples

• Children
• Mothers
• Fathers

General information	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Home address	X	X	X		X				X				X				X
School address					X				X				X

Birth outcomes
Birth weight	X
Birth length	X
Gestational age at birth	X
Apgar score
Congenital malformations
Stillbirth (>= 22 weeks)
Child’s sex	X
Head circumference
Biparietal diameter

Child exposures	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Breast feeding		X	X
Diet		X	X						X				X				X
Dietary supplements		X							X				X				X
Childcare attendance			X		X
Active smoking													X				X
Passive smoking	X	X	X		X				X				X				X
Alcohol consumption
Physical activity									X				X				X
Substance use
Medicine intake		X	X		X				X				X				X
Vaccinations		X
Psychological distress (e.g. bullying)
Air pollution													X				X
Access to green spaces
Built environment
Noise																			X
Radiation, electromagnetic fields
Water contamination
Pets	X	X	X		X				X				X				X
Farm animal exposure	X				X				X
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A					X
Other bisphenols					X
Parabens
Benzophenones
Triclosan
Phthalates					X
Cotinine																	X

Child development and health	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Anthropometry
Weight	X				X				X				X				X
Height					X				X				X				X
Head circumference	X
Abdominal circumference
Arm circumference
Wrist circumference
Waist circumference
Clinical examinations
Blood pressure																	X
Carotida intima media thickness
Pulse wave velocity
Cardiac ultrasound
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan results
Skin folds
Bio impedence
Oscilometry																	X
Spirometry									X								X
Skin prick test			X
Bronchial challenge test
Reversibility test
Dental observations
Mental and neurological development
Cognitive function
School performance
Language
ADHD													X
Autism
Sleep disturbances																	X
Mental health
Respiratory health
Asthma		X	X		X				X				X				X
Allergy		X	X		X				X				X				X
Allergic rhinitis		X	X		X				X				X				X
Eczema		X	X		X				X				X				X
Respiratory tract infections		X	X		X												X
Senses
Vision
Hearing																			X
Musculo-skeletal health
Back pain
Neck pain
Growing pains
Sexual maturation
Tanner stage
Pubertal development stage													X				X
Age at menarche													X				X
Age at voice change
2D/4D digit ratio
Nocturnal ejaculation
Acne													X				X
Other health outcomes
Cancer
Diabetes													X
Congenital anomalies
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)																	X
Immunologic markers (e.g. immunoglobulines)
Cortisol																	X
Vitamines and micronutrients									X
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics									X								X
DNA methylation					X				X								X
Transcriptomics (mRNA, miRNA)																	X
Genome-wide association study (GWAS)					X				X								X

Child biological samples	---------- Child age (years) at sampling ----------
	At birth	0	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Whole blood
Serum
Plasma						X				X								X
Buffy coat
Urine						X
Hair
Teeth
Nails
Saliva																		X
Purified DNA						X				X								X
Purified RNA																		X
Red blood cells
Umbilical cord blood/tissue
Blood smear
Faeces/meconium
Exhaled breathe condensate
Sputum induction
Placenta

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education			X
Income
Employment status			X
Job title			X								X
Single parenthood
Home address			X	X	X		X				X				X				X
Work address

Maternal characteristics related to the index pregnancy/child
Age at birth	X
Ethnicity
Country of birth	X
Planned pregnancy
Time to pregnancy
Fertility treatment
Prior spontaneous abortion (<22w)
Prior births
Ultrasound measurements
Doppler measurements
Preeclampsia
Gestational diabetes
Gestational hypertension
Gestational duration	X
Mode of delivery
Prenatal diagnostics
Medical termination of pregnancy

Maternal Exposures	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Diet
Dietary supplements
Active smoking		X	X	X	X
Passive smoking					X
Alcohol consumption
Physical activity
Substance use
Medicine intake					X
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets					X
Farm animal exposure					X
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Maternal health	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Anthropometry
Weight
Height
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma					X
Allergy					X
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer
Diabetes					X
Cardio‐vascular disease					X
Family history of chronic disease
Infectious disease
Fever
Autoimmune disease
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Maternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Breast milk
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education			X
Income
Employment status			X
Job title			X								X
Single parenthood
Home address			X	X	X		X				X				X				X
Work address

Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birth	X
Ethnicity
Country of birth	X

Paternal exposures	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Diet
Dietary supplements
Active smoking		X	X
Passive smoking		X	X
Alcohol consumption
Physical activity
Substance use
Medicine intake			X
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets			X
Farm animal exposure			X
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Paternal health	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Anthropometry
Weight
Height
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma			X
Allergy			X
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer
Diabetes			X
Cardio‐vascular disease			X
Family history of chronic disease
Infectious disease
Fever
Autoimmune disease
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Paternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Semen
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces

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