- Cohort, name
Hamamatsu Birth Cohort for Mothers and Children
Cohort, abbreviation
HBC Study
Cohort, country
Japan (日本)
Key reference
Takagai S, Tsuchiya KJ, Itoh H, Kanayama N, Mori N, Takei N, for HBC Study Team. Cohort profile: Hamamatsu Birth Cohort for Mothers and Children (HBC Study). International Journal of Epidemiology 45(2): 333-342, 2016.
Date of filling in this questionnaire:
2016-05-01 - Principal investigator(s), name
Kenji J. Tsuchiya
Principal investigator(s), e-mail address
tsuchiya@hama-med.ac.jp
Principal investigator(s), institution
Hamamatsu University School of Medicine
Contact person(s), name
Prof. Kenji J. Tsuchiya
Contact person(s), e-mail address
tsuchiya@hama-med.ac.jp
Contact person(s), institution address
Handayama 1 Higashiku, Hamamatsu 4313192
- Main aim of cohort
Main aims To capture neurodevelopmental trajectories of children with autism spectrum disorder To explore consequences of LBW children in Japan (NB: proportion of LBW neonates has been dramatically increasing for the last two decades) Exposures of interest -- Low birth weight -- Artificial Reproduction -- Neurodevelopment measures during the first year of life Outcomes of interest -- Autism spectrum disorder and other neurodevelopmental abnormalities -- Allergic diseases
Recruited number of:
1258 children / 1138 mothers / 0 fathers / 0 grand parents / 0 other family members
Approximate proportion of source population included
5
Source population
Other, please describeHospital-based - Period of enrollment
Start: 2007-11-19, End: 2012-03-31
Enrollment period
Pregnancy, week 16 to 28
Enrollment criteria, please specify
Parturients visiting two maternity clinics in Hamamatsu City
Exclusion criteria, please specify
Those who are unwilling to participate (ca. 20%)
Planned age of children at end of follow-up
8 years
General information | ---------- Child age (years) at assessment ---------- | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
<1 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | >18 | |
Home address | X | X | X | X | X | X | X | X | ||||||||||||
School address | X | X |
Birth outcomes | |
---|---|
Birth weight | X |
Birth length | X |
Gestational age at birth | X |
Apgar score | X |
Congenital malformations | |
Stillbirth (>= 22 weeks) | X |
Child’s sex | X |
Head circumference | X |
Biparietal diameter |
Child exposures | ---------- Child age (years) at assessment ---------- | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
<1 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | >18 | |
Breast feeding | X | X | X | X | ||||||||||||||||
Diet | X | X | X | X | X | X | ||||||||||||||
Dietary supplements | ||||||||||||||||||||
Childcare attendance | X | X | X | X | ||||||||||||||||
Active smoking | ||||||||||||||||||||
Passive smoking | X | X | X | X | ||||||||||||||||
Alcohol consumption | ||||||||||||||||||||
Physical activity | X | X | X | X | ||||||||||||||||
Substance use | ||||||||||||||||||||
Medicine intake | X | X | X | X | X | X | X | X | ||||||||||||
Vaccinations | ||||||||||||||||||||
Psychological distress (e.g. bullying) | X | X | X | |||||||||||||||||
Air pollution | ||||||||||||||||||||
Access to green spaces | ||||||||||||||||||||
Built environment | ||||||||||||||||||||
Noise | ||||||||||||||||||||
Radiation, electromagnetic fields | ||||||||||||||||||||
Water contamination | ||||||||||||||||||||
Pets | X | X | ||||||||||||||||||
Farm animal exposure | ||||||||||||||||||||
Biomarkers of exposure | ||||||||||||||||||||
Mercury | X | |||||||||||||||||||
Lead | ||||||||||||||||||||
Cadmium | ||||||||||||||||||||
Arsenic | X | |||||||||||||||||||
Other metals | X | |||||||||||||||||||
Polychlorinated biphenyl esters | ||||||||||||||||||||
Dicloro difenil tricloroetano | ||||||||||||||||||||
Hexachlorobenzene | ||||||||||||||||||||
Brominated flame retardants | ||||||||||||||||||||
Perflouralkyl compounds | X | |||||||||||||||||||
Bisphenol A | ||||||||||||||||||||
Other bisphenols | ||||||||||||||||||||
Parabens | ||||||||||||||||||||
Benzophenones | ||||||||||||||||||||
Triclosan | ||||||||||||||||||||
Phthalates | X | |||||||||||||||||||
Cotinine |
Child development and health | ---------- Child age (years) at assessment ---------- | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
<1 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | >18 | |
Anthropometry | ||||||||||||||||||||
Weight | X | X | X | X | X | X | X | X | ||||||||||||
Height | X | X | X | X | X | X | X | |||||||||||||
Head circumference | X | X | X | X | X | |||||||||||||||
Abdominal circumference | ||||||||||||||||||||
Arm circumference | ||||||||||||||||||||
Wrist circumference | ||||||||||||||||||||
Waist circumference | ||||||||||||||||||||
Clinical examinations | ||||||||||||||||||||
Blood pressure | ||||||||||||||||||||
Carotida intima media thickness | ||||||||||||||||||||
Pulse wave velocity | ||||||||||||||||||||
Cardiac ultrasound | X | |||||||||||||||||||
Renal ultrasound | ||||||||||||||||||||
Brain MRI | ||||||||||||||||||||
Other MRI | ||||||||||||||||||||
DEXA‐scan results | ||||||||||||||||||||
Skin folds | X | |||||||||||||||||||
Bio impedence | X | |||||||||||||||||||
Oscilometry | ||||||||||||||||||||
Spirometry | ||||||||||||||||||||
Skin prick test | ||||||||||||||||||||
Bronchial challenge test | ||||||||||||||||||||
Reversibility test | ||||||||||||||||||||
Dental observations | ||||||||||||||||||||
Mental and neurological development | ||||||||||||||||||||
Cognitive function | X | X | X | X | X | X | ||||||||||||||
School performance | ||||||||||||||||||||
Language | X | X | X | X | ||||||||||||||||
ADHD | X | X | X | X | ||||||||||||||||
Autism | X | X | X | X | X | X | X | |||||||||||||
Sleep disturbances | X | X | X | X | ||||||||||||||||
Mental health | X | X | X | X | X | X | X | X | ||||||||||||
Respiratory health | ||||||||||||||||||||
Asthma | X | X | X | X | ||||||||||||||||
Allergy | X | X | X | X | ||||||||||||||||
Allergic rhinitis | X | X | X | X | ||||||||||||||||
Eczema | X | X | X | X | ||||||||||||||||
Respiratory tract infections | X | X | X | X | ||||||||||||||||
Senses | ||||||||||||||||||||
Vision | X | |||||||||||||||||||
Hearing | ||||||||||||||||||||
Musculo-skeletal health | ||||||||||||||||||||
Back pain | ||||||||||||||||||||
Neck pain | ||||||||||||||||||||
Growing pains | ||||||||||||||||||||
Sexual maturation | ||||||||||||||||||||
Tanner stage | ||||||||||||||||||||
Pubertal development stage | X | |||||||||||||||||||
Age at menarche | X | |||||||||||||||||||
Age at voice change | X | |||||||||||||||||||
2D/4D digit ratio | ||||||||||||||||||||
Nocturnal ejaculation | ||||||||||||||||||||
Acne | ||||||||||||||||||||
Other health outcomes | ||||||||||||||||||||
Cancer | X | X | ||||||||||||||||||
Diabetes | ||||||||||||||||||||
Congenital anomalies | X | X | ||||||||||||||||||
Biomarkers of health | ||||||||||||||||||||
Nephrology (e.g. creatinine, albumin) | ||||||||||||||||||||
Thyroid hormones | X | |||||||||||||||||||
Inflammatory markers (e.g. C-reactive protein cytokines) | X | |||||||||||||||||||
Immunologic markers (e.g. immunoglobulines) | X | |||||||||||||||||||
Cortisol | X | |||||||||||||||||||
Vitamines and micronutrients | X | |||||||||||||||||||
Gonadal axis hormones (e.g. testosterone, estradiol) | X | |||||||||||||||||||
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides) | X | |||||||||||||||||||
Metabolomics | X | |||||||||||||||||||
DNA methylation | ||||||||||||||||||||
Transcriptomics (mRNA, miRNA) | X | |||||||||||||||||||
Genome-wide association study (GWAS) | X |
Child biological samples | ---------- Child age (years) at sampling ---------- | ||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
At birth | 0 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | >18 | |
Whole blood | |||||||||||||||||||||
Serum | |||||||||||||||||||||
Plasma | |||||||||||||||||||||
Buffy coat | |||||||||||||||||||||
Urine | |||||||||||||||||||||
Hair | |||||||||||||||||||||
Teeth | |||||||||||||||||||||
Nails | |||||||||||||||||||||
Saliva | |||||||||||||||||||||
Purified DNA | X | ||||||||||||||||||||
Purified RNA | |||||||||||||||||||||
Red blood cells | |||||||||||||||||||||
Umbilical cord blood/tissue | X | ||||||||||||||||||||
Blood smear | |||||||||||||||||||||
Faeces/meconium | |||||||||||||||||||||
Exhaled breathe condensate | |||||||||||||||||||||
Sputum induction | |||||||||||||||||||||
Placenta | X |
General information | |||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Pre-pregnancy | During pregnancy | <1 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | |
Education | X | ||||||||||||||||||||
Income | X | X | X | ||||||||||||||||||
Employment status | X | X | X | X | X | X | X | X | X | X | |||||||||||
Job title | X | X | X | X | X | X | X | X | X | ||||||||||||
Single parenthood | X | X | X | ||||||||||||||||||
Home address | X | X | X | X | X | X | X | X | X | ||||||||||||
Work address |
Maternal characteristics related to the index pregnancy/child | |
---|---|
Age at birth | X |
Ethnicity | X |
Country of birth | |
Planned pregnancy | X |
Time to pregnancy | X |
Fertility treatment | X |
Prior spontaneous abortion (<22w) | X |
Prior births | X |
Ultrasound measurements | X |
Doppler measurements | |
Preeclampsia | X |
Gestational diabetes | |
Gestational hypertension | |
Gestational duration | X |
Mode of delivery | X |
Prenatal diagnostics | X |
Medical termination of pregnancy |
Maternal Exposures | ---------- Timing of assessment ---------- | ||||
---|---|---|---|---|---|
Pre-pregnancy | First trimester | Second trimester | Third trimester | Post pregnancy | |
Diet | |||||
Dietary supplements | X | X | |||
Active smoking | X | X | |||
Passive smoking | |||||
Alcohol consumption | X | X | |||
Physical activity | |||||
Substance use | X | X | |||
Medicine intake | X | X | |||
Coffee drinking | |||||
Psychological distress (e.g. life-events, health behaviors, perceived stress) | X | X | |||
Occupational exposures | |||||
Heavy lifts | |||||
Work hours | |||||
Air pollution | |||||
Access to green spaces | |||||
Built environment | |||||
Noise | |||||
Radiation, electromagnetic fields | |||||
Water contamination | |||||
Binge drinking | |||||
Pets | |||||
Farm animal exposure | |||||
Biomarkers of exposure | |||||
Mercury | |||||
Lead | |||||
Cadmium | |||||
Arsenic | |||||
Other metals | |||||
Polychlorinated biphenyl esters | |||||
Dicloro difenil tricloroetano | |||||
Hexachlorobenzene | |||||
Brominated flame retardants | |||||
Perflouralkyl compounds | |||||
Bisphenol A | |||||
Other bisphenols | |||||
Parabens | |||||
Benzophenones | |||||
Triclosan | |||||
Phthalates | |||||
Cotinine |
Maternal health | ---------- Timing of assessment ---------- | ||||
---|---|---|---|---|---|
Pre-pregnancy | First trimester | Second trimester | Third trimester | Post pregnancy | |
Anthropometry | |||||
Weight | X | X | X | ||
Height | X | X | |||
Waist circumference | |||||
Clinical examinations | |||||
Blood pressure | |||||
Carotida intima media thickness | |||||
Pulse wave velocity | |||||
DEXA scans | |||||
Bioimpedence | |||||
Mental and neurological development | |||||
Mental health | X | X | |||
Cognitive function (e.g. intelligence quotient) | |||||
Respiratory health | |||||
Asthma | X | X | |||
Allergy | X | X | |||
Musculo‐skeletal disease | X | X | |||
Back pain | |||||
Neck pain | |||||
Arthritis | |||||
Other health outcomes | |||||
Cancer | X | X | |||
Diabetes | X | X | |||
Cardio‐vascular disease | X | X | |||
Family history of chronic disease | X | X | |||
Infectious disease | X | X | |||
Fever | X | X | |||
Autoimmune disease | X | X | |||
Urinary symptoms | X | X | |||
Sexual problems | |||||
Sleep disturbance | X | ||||
Biomarkers of health | |||||
Nephrology (e.g. creatinine, albumin) | |||||
Thyroid hormones | |||||
Inflammatory markers (e.g. C-reactive protein cytokines) | |||||
Immunologic markers (e.g. immunoglobulines) | |||||
Cortisol | |||||
Vitamines and micronutrients | |||||
Gonadal axis hormones (e.g. testosterone, estradiol) | |||||
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides) | |||||
Metabolomics | |||||
DNA methylation | |||||
Transcriptomics (mRNA, miRNA) | |||||
Genome-wide association study (GWAS) |
Maternal biological samples | ---------- Timing of sampling ---------- | ||||
---|---|---|---|---|---|
Pre-pregnancy | First trimester | Second trimester | Third trimester | Post pregnancy | |
Breast milk | |||||
Whole blood | |||||
Serum | |||||
Plasma | |||||
Buffy coat | |||||
Urine | |||||
Hair | |||||
Nails | |||||
Saliva | |||||
Purified DNA | X | ||||
Purified RNA | |||||
Red blood cells | |||||
Faeces |
General information | |||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Pre-pregnancy | During pregnancy | <1 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | |
Education | X | ||||||||||||||||||||
Income | X | X | X | X | X | ||||||||||||||||
Employment status | X | X | X | X | X | X | X | X | X | ||||||||||||
Job title | X | X | X | X | X | X | X | X | X | ||||||||||||
Single parenthood | X | X | X | ||||||||||||||||||
Home address | X | X | |||||||||||||||||||
Work address |
Paternal characteristics related to the index pregnancy/child | |
---|---|
Fertility treatment | |
Age at child's birth | X |
Ethnicity | X |
Country of birth |
Paternal exposures | ---------- Timing of assessment ---------- | ||
---|---|---|---|
Pre-pregnancy | During pregnancy | Post pregnancy | |
Diet | |||
Dietary supplements | |||
Active smoking | X | ||
Passive smoking | |||
Alcohol consumption | X | ||
Physical activity | |||
Substance use | X | ||
Medicine intake | |||
Coffee drinking | |||
Psychological distress (e.g. life-events, health behaviors, perceived stress) | |||
Occupational exposures | X | ||
Heavy lifts | |||
Work hours | |||
Air pollution | |||
Access to green spaces | |||
Built environment | |||
Noise | |||
Radiation, electromagnetic fields | |||
Water contamination | |||
Binge drinking | |||
Pets | |||
Farm animal exposure | |||
Biomarkers of exposure | |||
Mercury | |||
Lead | |||
Cadmium | |||
Arsenic | |||
Other metals | |||
Polychlorinated biphenyl esters | |||
Dicloro difenil tricloroetano | |||
Hexachlorobenzene | |||
Brominated flame retardants | |||
Perflouralkyl compounds | |||
Bisphenol A | |||
Other bisphenols | |||
Parabens | |||
Benzophenones | |||
Triclosan | |||
Phthalates | |||
Cotinine |
Paternal health | ---------- Timing of assessment ---------- | ||
---|---|---|---|
Pre-pregnancy | During pregnancy | Post pregnancy | |
Anthropometry | |||
Weight | |||
Height | |||
Waist circumference | |||
Clinical examinations | |||
Blood pressure | |||
Carotida intima media thickness | |||
Pulse wave velocity | |||
DEXA scans | |||
Bio impedence | |||
Mental and neurological development | |||
Mental health | X | X | |
Cognitive function (e.g. intelligence quotient) | |||
Respiratory health | |||
Asthma | |||
Allergy | |||
Musculo‐skeletal disease | |||
Back pain | |||
Neck pain | |||
Arthritis | |||
Other health outcomes | |||
Cancer | |||
Diabetes | |||
Cardio‐vascular disease | |||
Family history of chronic disease | |||
Infectious disease | |||
Fever | |||
Autoimmune disease | |||
Urinary symptoms | |||
Sexual problems | |||
Sleep disturbance | |||
Biomarkers of health | |||
Nephrology (e.g. creatinine, albumin) | |||
Thyroid hormones | |||
Inflammatory markers (e.g. C-reactive protein cytokines) | |||
Immunologic markers (e.g. immunoglobulines) | |||
Cortisol | |||
Vitamines and micronutrients | |||
Gonadal axis hormones (e.g. testosterone, estradiol) | |||
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides) | |||
Metabolomics | |||
DNA methylation | |||
Transcriptomics (mRNA, miRNA) | |||
Genome-wide association study (GWAS) |
Paternal biological samples | ---------- Timing of sampling ---------- | ||
---|---|---|---|
Pre-pregnancy | During pregnancy | Post pregnancy | |
Semen | |||
Whole blood | |||
Serum | |||
Plasma | |||
Buffy coat | |||
Urine | |||
Hair | |||
Nails | |||
Saliva | |||
Purified DNA | X | ||
Purified RNA | |||
Red blood cells | |||
Faeces |
Comments and ideas
The follow-up period, currently 8 years, will be extended.
The follow-up period, currently 8 years, will be extended.