Identification

• Cohort, name
  LucKi
  
  Cohort, abbreviation
  LucKi
  
  Cohort, country
  Netherlands (Nederland)
  
  Cohort, website
  http://www.luckistudie.nl
  
  Key reference
  de Korte-de Boer D, Mommers M, Creemers HM, Dompeling E, Feron FJ, Gielkens-Sijstermans CM, Jaminon M, Mujakovic S, van Schayck OC, Thijs C, Jansen M. LucKi Birth Cohort Study: rationale and design. BMC Public Health. 2015 Sep 21;15:934.
  
  Date of filling in this questionnaire:
  2014-02-27
  
  
• Principal investigator(s), name
  Monique Mommers / Suhreta Mujakovic
  
  Principal investigator(s), e-mail address
  monique.mommers@maastrichtuniversity.nl
  
  Principal investigator(s), institution
  Maastricht University / Public Health Service South-Limburg
  
  Contact person(s), institution address
  Maastricht University, PO Box 616, 6200 MD Maastricht, the Netherlands
  
  

Basic description

• Main aim of cohort
  The main aim is to study the etiology and prognosis of atopic diseases and overweight. Main outcomes: asthma, eczema, hay fever, infections, over(weight) development. Main exposures: lifestyle, nutrition, physical activity, indoor and outdoor environment, parental occupation.
  
  Recruited number of:
  5000 children / 0 mothers / 0 fathers / 0 grand parents / 0 other family members
  
  Approximate proportion of source population included
  0
  
  Source population
  Region-based
  
  
• Period of enrollment
  Start: 2006-07-01, End: 0000-00-00
  
  Enrollment period
  Later, month 0 to 1
  
  Enrollment criteria, please specify
  General population, living in the south-eastern region of the Netherlands (Westelijke Mijnstreek).
  
  Exclusion criteria, please specify
  No exclusion criteria.
  
  Planned age of children at end of follow-up
  

Questionnaire or registry data and biological samples

• Children
• Mothers
• Fathers

General information	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Home address
School address

Birth outcomes
Birth weight	X
Birth length	X
Gestational age at birth	X
Apgar score
Congenital malformations
Stillbirth (>= 22 weeks)
Child’s sex	X
Head circumference
Biparietal diameter

Child exposures	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Breast feeding	X	X
Diet	X	X		X			X
Dietary supplements	X	X		X			X
Childcare attendance	X	X		X			X
Active smoking
Passive smoking	X	X		X			X
Alcohol consumption
Physical activity				X			X
Substance use
Medicine intake	X	X	X	X	X	X	X
Vaccinations	X	X	X	X	X	X	X
Psychological distress (e.g. bullying)
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Pets	X	X		X			X
Farm animal exposure	X
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Child development and health	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Anthropometry
Weight	X	X	X	X	X	X	X
Height	X	X	X	X	X	X	X
Head circumference	X	X	X	X	X	X	X
Abdominal circumference
Arm circumference
Wrist circumference
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
Cardiac ultrasound
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan results
Skin folds
Bio impedence
Oscilometry
Spirometry
Skin prick test
Bronchial challenge test
Reversibility test
Dental observations
Mental and neurological development
Cognitive function
School performance
Language
ADHD
Autism
Sleep disturbances
Mental health
Respiratory health
Asthma	X	X		X			X
Allergy	X	X		X			X
Allergic rhinitis							X
Eczema	X	X		X			X
Respiratory tract infections	X	X		X			X
Senses
Vision
Hearing
Musculo-skeletal health
Back pain
Neck pain
Growing pains
Sexual maturation
Tanner stage
Pubertal development stage
Age at menarche
Age at voice change
2D/4D digit ratio
Nocturnal ejaculation
Acne
Other health outcomes
Cancer
Diabetes
Congenital anomalies
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Child biological samples	---------- Child age (years) at sampling ----------
	At birth	0	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Teeth
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Umbilical cord blood/tissue
Blood smear
Faeces/meconium		X	X
Exhaled breathe condensate
Sputum induction
Placenta

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education			X
Income
Employment status									X
Job title									X
Single parenthood
Home address
Work address

Maternal characteristics related to the index pregnancy/child
Age at birth	X
Ethnicity	X
Country of birth	X
Planned pregnancy
Time to pregnancy
Fertility treatment
Prior spontaneous abortion (<22w)
Prior births	X
Ultrasound measurements
Doppler measurements
Preeclampsia
Gestational diabetes
Gestational hypertension
Gestational duration	X
Mode of delivery	X
Prenatal diagnostics
Medical termination of pregnancy

Maternal Exposures	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Diet				X	X
Dietary supplements		X	X	X	X
Active smoking	X	X	X	X	X
Passive smoking				X	X
Alcohol consumption		X	X	X	X
Physical activity					X
Substance use
Medicine intake		X	X	X	X
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures				X	X
Heavy lifts
Work hours					X
Air pollution					X
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets				X	X
Farm animal exposure				X	X
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Maternal health	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Anthropometry
Weight	X			X	X
Height	X			X	X
Waist circumference
Clinical examinations
Blood pressure					X
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma				X	X
Allergy				X	X
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis					X
Other health outcomes
Cancer
Diabetes				X	X
Cardio‐vascular disease					X
Family history of chronic disease					X
Infectious disease		X	X	X
Fever		X	X	X
Autoimmune disease				X	X
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Maternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Breast milk
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces					X

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education			X
Income
Employment status									X
Job title									X
Single parenthood
Home address
Work address

Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birth	X
Ethnicity	X
Country of birth	X

Paternal exposures	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Diet
Dietary supplements
Active smoking		X	X
Passive smoking		X	X
Alcohol consumption
Physical activity			X
Substance use
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures			X
Heavy lifts
Work hours			X
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Paternal health	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Anthropometry
Weight			X
Height			X
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma			X
Allergy			X
Musculo‐skeletal disease			X
Back pain
Neck pain
Arthritis			X
Other health outcomes
Cancer
Diabetes			X
Cardio‐vascular disease			X
Family history of chronic disease			X
Infectious disease
Fever
Autoimmune disease			X
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Paternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Semen
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces

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