Identification

• Cohort, name
  Copenhagen Prospective Studies on Asthma in Childhood 2010
  
  Cohort, abbreviation
  COPSAC2010
  
  Cohort, country
  Denmark (Danmark)
  
  Cohort, website
  http://www.copsac.com
  
  Key reference
  Deep phenotyping of the unselected COPSAC2010 birth cohort study. Clin Exp Allergy. 2013 Dec;43(12):1384-94.
  
  Date of filling in this questionnaire:
  2016-03-18
  
  
• Principal investigator(s), name
  Klaus Bønnelykke
  
  Principal investigator(s), e-mail address
  kb@copsac.com
  
  Principal investigator(s), institution
  Copenhagen Prospective Studies on Asthma in Childhood
  
  Contact person(s), name
  Klaus Bønnelykke
  
  Contact person(s), e-mail address
  kb@copsac.com
  
  Contact person(s), institution address
  Ledreborg Allé 34, DK-2820 Gentofte, Denmark
  
  

Basic description

• Main aim of cohort
  To investigate perinatal exposures, in particular the human microbiome and maternal nutrition during pregnancy, interact with the genetic predisposition to cause an abnormal immune modulation in early life towards a trajectory to chronic inflammatory diseases such as asthma and others. Randomized controlled trials of high-dose vitamin D and fish oil supplements were conducted during pregnancy, and a trial of azithromycin for acute lung symptoms was conducted in the children with recurrent wheeze.
  
  Recruited number of:
  743 children / 733 mothers / 733 fathers / 0 grand parents / 0 other family members
  
  Approximate proportion of source population included
  3
  
  Source population
  Region-based
  
  
• Period of enrollment
  Start: 2008-02-01, End: 2010-08-01
  
  Enrollment period
  Pregnancy, week 24 to 24
  
  Enrollment criteria, please specify
  - Must recide in Zealand. - Positively interested participating in COPSAC.
  
  Exclusion criteria, please specify
  - Gestational age above week 26. - Daily intake of more than 600 IU vitamin D during pregnancy. - Having any endocrine, heart, or kidney disorders.
  
  Planned age of children at end of follow-up
  Life-long / unrestricted

Questionnaire or registry data and biological samples

• Children
• Mothers
• Fathers

General information	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Home address
School address

Birth outcomes
Birth weight	X
Birth length	X
Gestational age at birth	X
Apgar score	X
Congenital malformations	X
Stillbirth (>= 22 weeks)	X
Child’s sex	X
Head circumference
Biparietal diameter

Child exposures	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Breast feeding	X	X	X	X
Diet	X	X
Dietary supplements
Childcare attendance	X	X	X	X	X	X	X
Active smoking
Passive smoking	X	X	X	X	X	X	X
Alcohol consumption
Physical activity			X
Substance use
Medicine intake	X	X	X	X	X	X	X
Vaccinations	X	X	X	X	X	X	X
Psychological distress (e.g. bullying)
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Child development and health	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Anthropometry
Weight	X	X	X	X	X	X	X
Height	X	X	X	X	X	X	X
Head circumference	X	X	X	X	X	X	X
Abdominal circumference
Arm circumference
Wrist circumference
Waist circumference
Clinical examinations
Blood pressure				X			X
Carotida intima media thickness
Pulse wave velocity
Cardiac ultrasound
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan results				X			X
Skin folds
Bio impedence
Oscilometry
Spirometry
Skin prick test
Bronchial challenge test
Reversibility test
Dental observations
Mental and neurological development
Cognitive function				X
School performance
Language				X
ADHD
Autism
Sleep disturbances			X
Mental health							X
Respiratory health
Asthma
Allergy
Allergic rhinitis
Eczema
Respiratory tract infections
Senses
Vision
Hearing
Musculo-skeletal health
Back pain
Neck pain
Growing pains
Sexual maturation
Tanner stage
Pubertal development stage
Age at menarche
Age at voice change
2D/4D digit ratio
Nocturnal ejaculation
Acne
Other health outcomes
Cancer	X	X	X	X	X	X	X
Diabetes	X	X	X	X	X	X	X
Congenital anomalies
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Child biological samples	---------- Child age (years) at sampling ----------
	At birth	0	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Whole blood			X	X				X
Serum			X	X				X
Plasma
Buffy coat
Urine		X	X					X
Hair		X	X	X				X
Teeth								X
Nails
Saliva								X
Purified DNA		X
Purified RNA
Red blood cells
Umbilical cord blood/tissue	X
Blood smear
Faeces/meconium
Exhaled breathe condensate
Sputum induction
Placenta

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education		X
Income		X
Employment status
Job title
Single parenthood		X
Home address
Work address

Maternal characteristics related to the index pregnancy/child
Age at birth	X
Ethnicity	X
Country of birth
Planned pregnancy
Time to pregnancy
Fertility treatment	X
Prior spontaneous abortion (<22w)	X
Prior births	X
Ultrasound measurements
Doppler measurements
Preeclampsia	X
Gestational diabetes
Gestational hypertension
Gestational duration	X
Mode of delivery	X
Prenatal diagnostics
Medical termination of pregnancy	X

Maternal Exposures	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Diet				X
Dietary supplements				X
Active smoking		X	X	X
Passive smoking		X	X	X
Alcohol consumption		X	X	X
Physical activity
Substance use
Medicine intake		X	X	X
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking		X	X	X
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Maternal health	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Anthropometry
Weight	X
Height	X	X	X	X	X
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal disease		X	X	X
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer		X	X	X
Diabetes		X	X	X
Cardio‐vascular disease		X	X	X
Family history of chronic disease
Infectious disease		X	X	X
Fever
Autoimmune disease		X	X	X
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Maternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Breast milk					X
Whole blood			X		X
Serum			X
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA			X
Purified RNA
Red blood cells
Faeces

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education		X
Income		X
Employment status
Job title
Single parenthood
Home address
Work address

Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birth	X
Ethnicity
Country of birth

Paternal exposures	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Diet
Dietary supplements
Active smoking
Passive smoking
Alcohol consumption
Physical activity
Substance use
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Paternal health	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Anthropometry
Weight
Height		X	X
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer
Diabetes
Cardio‐vascular disease
Family history of chronic disease
Infectious disease
Fever
Autoimmune disease
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Paternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Semen
Whole blood		X
Serum		X
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA		X
Purified RNA
Red blood cells
Faeces

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