Identification

• Cohort, name
  Kuopio Birth Cohort
  
  Cohort, abbreviation
  KuBiCo
  
  Cohort, country
  Finland (Suomi)
  
  Cohort, website
  http://www.kubico.fi/
  
  Cohort, facebook-site
  KuBiCo- Kuopion syntymäkohorttitutkimus
  
  Date of filling in this questionnaire:
  2017-11-21
  
  
• Principal investigator(s), name
  Leea Keski-Nisula
  
  Principal investigator(s), e-mail address
  leea.keski-nisula@kuh.fi
  
  Principal investigator(s), institution
  Kuopio University Hospital
  
  Contact person(s), name
  Anne Karvonen
  
  Contact person(s), e-mail address
  anne.karvonen@thl.fi
  
  Contact person(s), institution address
  Finnish Institute for Health and Welfare (THL), P.O.Box 95, FIN-70701 Kuopio, Finland
  
  

Basic description

• Main aim of cohort
  The KuBiCo is aimed to resolve effects of genetics and different stress factors (medicines, nutrition, lifestyle factors and environmental aspects) during pregnancy on health status of the mother and the child.
  
  Recruited number of:
  4700 children / 4700 mothers / 0 fathers / 0 grand parents / 0 other family members
  
  Approximate proportion of source population included
  0
  
  Source population
  Region-based
  
  
• Period of enrollment
  Start: 2012-06-01, End: 0000-00-00
  
  Enrollment period
  Pregnancy, week  to
  
  Enrollment criteria, please specify
  All pregnant women who will give a birth at Kuopio University Hospital can participate in the KuBiCo project.
  
  Planned age of children at end of follow-up
  

Questionnaire or registry data and biological samples

• Children
• Mothers
• Fathers

General information	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Home address				X	X
School address

Birth outcomes
Birth weight	X
Birth length	X
Gestational age at birth	X
Apgar score	X
Congenital malformations	X
Stillbirth (>= 22 weeks)	X
Child’s sex	X
Head circumference	X
Biparietal diameter	X

Child exposures	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Breast feeding	X	X	X
Diet			X
Dietary supplements		X	X	X	X
Childcare attendance	X	X	X	X	X
Active smoking
Passive smoking		X	X	X	X
Alcohol consumption
Physical activity				X	X
Substance use
Medicine intake	X	X	X	X	X
Vaccinations		X	X	X	X
Psychological distress (e.g. bullying)
Air pollution
Access to green spaces
Built environment		X	X		X
Noise
Radiation, electromagnetic fields
Water contamination
Pets		X	X		X
Farm animal exposure		X	X		X
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Child development and health	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Anthropometry
Weight	X	X	X	X	X
Height	X	X	X	X	X
Head circumference	X	X	X	X	X
Abdominal circumference
Arm circumference
Wrist circumference
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
Cardiac ultrasound
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan results
Skin folds
Bio impedence
Oscilometry
Spirometry
Skin prick test
Bronchial challenge test
Reversibility test
Dental observations
Mental and neurological development
Cognitive function
School performance
Language
ADHD
Autism
Sleep disturbances
Mental health
Respiratory health
Asthma	X	X	X	X	X
Allergy	X	X	X	X	X
Allergic rhinitis	X	X	X	X	X
Eczema	X	X	X	X	X
Respiratory tract infections	X	X	X	X	X
Senses
Vision
Hearing
Musculo-skeletal health
Back pain
Neck pain
Growing pains
Sexual maturation
Tanner stage
Pubertal development stage
Age at menarche
Age at voice change
2D/4D digit ratio
Nocturnal ejaculation
Acne
Other health outcomes
Cancer
Diabetes
Congenital anomalies
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Child biological samples	---------- Child age (years) at sampling ----------
	At birth	0	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Whole blood							X
Serum							X
Plasma							X
Buffy coat
Urine
Hair	X						X
Teeth
Nails
Saliva	X
Purified DNA
Purified RNA
Red blood cells
Umbilical cord blood/tissue	X
Blood smear
Faeces/meconium
Exhaled breathe condensate
Sputum induction
Placenta	X

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education		X
Income
Employment status	X
Job title		X
Single parenthood		X		X	X	X	X
Home address		X				X	X
Work address

Maternal characteristics related to the index pregnancy/child
Age at birth	X
Ethnicity
Country of birth
Planned pregnancy
Time to pregnancy
Fertility treatment	X
Prior spontaneous abortion (<22w)	X
Prior births	X
Ultrasound measurements	X
Doppler measurements
Preeclampsia	X
Gestational diabetes	X
Gestational hypertension	X
Gestational duration	X
Mode of delivery
Prenatal diagnostics
Medical termination of pregnancy

Maternal Exposures	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Diet	X	X		X
Dietary supplements		X		X
Active smoking	X	X	X	X	X
Passive smoking	X	X	X	X	X
Alcohol consumption	X	X	X	X	X
Physical activity	X	X	X	X
Substance use	X	X	X	X
Medicine intake	X	X	X	X
Coffee drinking		X		X
Psychological distress (e.g. life-events, health behaviors, perceived stress)				X
Occupational exposures
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment		X
Noise		X
Radiation, electromagnetic fields		X	X	X
Water contamination
Binge drinking	X	X
Pets		X			X
Farm animal exposure		X			X
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Maternal health	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Anthropometry
Weight	X	X
Height	X	X
Waist circumference
Clinical examinations
Blood pressure		X	X	X
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence
Mental and neurological development
Mental health	X	X		X
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma	X	X	X	X
Allergy	X	X	X	X
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis	X	X
Other health outcomes
Cancer	X	X
Diabetes	X	X
Cardio‐vascular disease	X	X
Family history of chronic disease	X	X
Infectious disease	X	X
Fever		X	X	X
Autoimmune disease	X	X
Urinary symptoms
Sexual problems
Sleep disturbance			X
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Maternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Breast milk
Whole blood				X
Serum		X
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education		X
Income
Employment status		X
Job title		X
Single parenthood
Home address
Work address

Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birth	X
Ethnicity
Country of birth

Paternal exposures	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Diet
Dietary supplements
Active smoking	X	X
Passive smoking
Alcohol consumption	X	X
Physical activity
Substance use	X	X
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking	X	X
Pets
Farm animal exposure	X	X
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Paternal health	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Anthropometry
Weight		X
Height		X
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental health	X	X
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma	X	X
Allergy	X	X
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis	X	X
Other health outcomes
Cancer	X	X
Diabetes	X	X
Cardio‐vascular disease	X	X
Family history of chronic disease	X	X
Infectious disease	X	X
Fever
Autoimmune disease	X	X
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Paternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Semen
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces

Comments and ideas

Comments and ideas