Birthcohort | Birthcohorts

Cohort, name
Project Viva: A Study of Health for The Next Generation

Cohort, abbreviation
Project Viva

Cohort, country
United States

Cohort, website
www.ProjectViva.org

Date of filling in this questionnaire:
2023-12-14
Principal investigator(s), name
Dr. Emily Oken; Dr. Marie-France Hivert

Principal investigator(s), e-mail address
project_viva@hphci.harvard.edu

Principal investigator(s), institution
Harvard Medical School; Harvard Pilgrim Health Care Institute

Contact person(s), e-mail address
project_viva@hphci.harvard.edu

Main aim of cohort
Project Viva is a ground breaking longitudinal research study of women and children that initiated in Eastern Massachusetts in 1999. The goal of Project Viva is to find ways to improve the health of mothers and their children by looking at the effects of mother's diet as well as other factors during pregnancy and after birth. The information we collect enables us to investigate, for example, the effects of diet on child development and obesity, how diet and the environment influence the development of asthma in children. These are just a few of the many things Project Viva is exploring, thanks to the dedicated women and their children who enrolled in the study.

Recruited number of:
2128 children / 2128 mothers / 0 fathers / 0 grand parents / 0 other family members

Approximate proportion of source population included
0

Source population
Region-based
Period of enrollment
Start: 1999-04-01, End: 2002-11-30

Enrollment period
Pregnancy, week 1 to 22

Exclusion criteria, please specify
Multiple gestation, inability to answer questions in English, gestational age ≥22 weeks at recruitment and plans to move away from the study area before delivery.

Planned age of children at end of follow-up
Life-long / unrestricted

Questionnaire or registry data and biological samples

General information	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Home address	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
School address															X	X	X	X

Birth outcomes
Birth weight	X
Birth length	X
Gestational age at birth	X
Apgar score	X
Congenital malformations
Stillbirth (>= 22 weeks)	X
Child’s sex	X
Head circumference	X
Biparietal diameter

Child exposures	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Breast feeding	X	X	X
Diet	X	X	X	X	X	X	X	X	X	X	X	X	X		X	X	X	X		X
Dietary supplements	X	X	X	X	X	X	X	X										X		X
Childcare attendance	X	X	X	X
Active smoking											X	X	X		X	X	X	X		X
Passive smoking	X	X	X	X				X	X	X	X	X	X		X	X	X	X		X
Alcohol consumption												X	X		X	X	X	X		X
Physical activity		X	X	X	X	X	X	X	X	X	X	X	X		X	X	X	X		X
Substance use																	X	X		X
Medicine intake		X	X	X	X	X	X	X					X		X	X	X	X		X
Vaccinations																				X
Psychological distress (e.g. bullying)													X					X		X
Air pollution	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Pets	X	X	X	X	X	X	X	X					X					X		X
Farm animal exposure
Biomarkers of exposure
Mercury	X			X
Lead				X				X
Cadmium				X				X
Arsenic				X				X
Other metals				X				X
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds	X							X
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates								X
Cotinine

Child development and health	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Anthropometry
Weight	X	X	X	X	X	X	X	X	X	X	X	X	X		X	X	X	X		X
Height	X	X	X	X	X	X	X	X	X	X	X	X	X		X	X	X	X		X
Head circumference
Abdominal circumference
Arm circumference				X				X					X					X
Wrist circumference
Waist circumference				X				X					X					X
Clinical examinations
Blood pressure	X			X				X					X					X
Carotida intima media thickness
Pulse wave velocity
Cardiac ultrasound
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan results								X					X					X
Skin folds								X					X					X
Bio impedence								X					X					X
Oscilometry
Spirometry								X					X					X
Skin prick test
Bronchial challenge test
Reversibility test
Dental observations
Mental and neurological development
Cognitive function				X				X
School performance																X
Language
ADHD													X		X	X	X	X
Autism								X					X					X
Sleep disturbances										X	X	X	X		X	X	X	X		X
Mental health												X	X		X	X	X	X		X
Respiratory health
Asthma	X	X	X	X	X	X	X	X	X	X	X	X	X		X	X	X	X		X
Allergy	X	X	X	X	X	X	X	X	X	X	X	X	X		X					X
Allergic rhinitis	X	X	X	X	X	X	X	X					X		X	X	X	X		X
Eczema	X	X	X	X	X	X	X	X					X					X		X
Respiratory tract infections	X	X	X	X	X	X	X	X					X					X
Senses
Vision	X
Hearing
Musculo-skeletal health
Back pain
Neck pain
Growing pains
Sexual maturation
Tanner stage												X	X		X	X	X	X
Pubertal development stage								X	X	X	X	X	X		X	X	X	X
Age at menarche										X	X	X	X		X	X	X	X		X
Age at voice change
2D/4D digit ratio
Nocturnal ejaculation
Acne																				X
Other health outcomes
Cancer								X					X					X
Diabetes													X					X
Congenital anomalies								X
Biomarkers of health
Nephrology (e.g. creatinine, albumin)																		X
Thyroid hormones	X
Inflammatory markers (e.g. C-reactive protein cytokines)				X				X					X					X
Immunologic markers (e.g. immunoglobulines)	X			X				X					X
Cortisol								X					X					X
Vitamines and micronutrients	X			X				X
Gonadal axis hormones (e.g. testosterone, estradiol)																		X
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)	X							X					X					X
Metabolomics	X							X					X					X
DNA methylation				X				X					X
Transcriptomics (mRNA, miRNA)				X
Genome-wide association study (GWAS)								X

Child biological samples	---------- Child age (years) at sampling ----------
	At birth	0	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Whole blood																			X
Serum					X				X					X
Plasma					X				X					X					X
Buffy coat
Urine									X					X					X
Hair									X					X					X
Teeth									X
Nails
Saliva
Purified DNA					X				X					X
Purified RNA														X
Red blood cells					X				X					X					X
Umbilical cord blood/tissue	X
Blood smear
Faeces/meconium
Exhaled breathe condensate
Sputum induction
Placenta

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education		X																			X
Income		X				X				X					X					X
Employment status		X	X	X	X	X		X	X	X					X					X
Job title
Single parenthood		X	X	X	X	X	X	X	X	X	X	X	X	X	X		X	X	X	X
Home address		X	X	X	X	X	X	X	X	X	X	X	X	X	X		X	X	X	X
Work address

Maternal characteristics related to the index pregnancy/child
Age at birth	X
Ethnicity	X
Country of birth	X
Planned pregnancy	X
Time to pregnancy	X
Fertility treatment	X
Prior spontaneous abortion (<22w)	X
Prior births	X
Ultrasound measurements	X
Doppler measurements
Preeclampsia	X
Gestational diabetes	X
Gestational hypertension	X
Gestational duration	X
Mode of delivery	X
Prenatal diagnostics	X
Medical termination of pregnancy

Maternal Exposures	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Diet		X	X		X
Dietary supplements		X	X		X
Active smoking		X	X		X
Passive smoking		X	X		X
Alcohol consumption		X	X		X
Physical activity	X	X	X		X
Substance use		X	X		X
Medicine intake		X	X		X
Coffee drinking		X	X		X
Psychological distress (e.g. life-events, health behaviors, perceived stress)	X	X	X		X
Occupational exposures
Heavy lifts
Work hours		X	X		X
Air pollution		X	X	X	X
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets					X
Farm animal exposure
Biomarkers of exposure
Mercury			X		X
Lead			X
Cadmium
Arsenic
Other metals		X	X
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds		X			X
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Maternal health	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Anthropometry
Weight	X	X	X	X	X
Height	X				X
Waist circumference					X
Clinical examinations
Blood pressure		X	X	X	X
Carotida intima media thickness
Pulse wave velocity
DEXA scans					X
Bioimpedence					X
Mental and neurological development
Mental health		X	X		X
Cognitive function (e.g. intelligence quotient)					X
Respiratory health
Asthma		X			X
Allergy		X			X
Musculo‐skeletal disease
Back pain					X
Neck pain
Arthritis					X
Other health outcomes
Cancer					X
Diabetes		X			X
Cardio‐vascular disease					X
Family history of chronic disease		X			X
Infectious disease
Fever
Autoimmune disease					X
Urinary symptoms
Sexual problems
Sleep disturbance					X
Biomarkers of health
Nephrology (e.g. creatinine, albumin)		X			X
Thyroid hormones		X
Inflammatory markers (e.g. C-reactive protein cytokines)		X			X
Immunologic markers (e.g. immunoglobulines)
Cortisol			X
Vitamines and micronutrients		X	X
Gonadal axis hormones (e.g. testosterone, estradiol)			X		X
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)			X		X
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)					X

Maternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Breast milk
Whole blood					X
Serum
Plasma		X	X		X
Buffy coat
Urine					X
Hair					X
Nails
Saliva
Purified DNA		X	X		X
Purified RNA
Red blood cells		X	X		X
Faeces

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education		X																			X
Income
Employment status
Job title
Single parenthood
Home address
Work address

Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birth	X
Ethnicity	X
Country of birth	X

Paternal exposures	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Diet
Dietary supplements
Active smoking
Passive smoking
Alcohol consumption
Physical activity
Substance use
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Paternal health	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Anthropometry
Weight		X	X
Height		X	X
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma		X	X
Allergy		X	X
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer
Diabetes		X	X
Cardio‐vascular disease			X
Family history of chronic disease		X	X
Infectious disease
Fever
Autoimmune disease			X
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Paternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Semen
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces

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