Birthcohort | Birthcohorts

Cohort, name
Generation Victoria Cohort 2020s

Cohort, abbreviation
GenV

Cohort, country
Australia

Cohort, website
https://www.genv.org.au/

Cohort, facebook-site
https://www.facebook.com/GenVforkids

Key reference
https://clinicaltrials.gov/ct2/show/NCT05394363

Date of filling in this questionnaire:
2023-10-30
Principal investigator(s), name
Prof. Melissa Wake

Principal investigator(s), institution
Murdoch Children's Research Institute (MCRI). The Royal Children's Hospital, 50 Flemington Road Parkville, Victoria 3052 Aust

Contact person(s), name
GenV Cohort Coordinator

Contact person(s), e-mail address
genv@mcri.edu.au

Contact person(s), institution address
Murdoch Children's Research Institute (MCRI). The Royal Children's Hospital, 50 Flemington Road Parkville, Victoria 3052 Australia

Main aim of cohort
Based at the Murdoch Children’s Research Institute (MCRI), GenV is recruiting large, parallel whole-of-state cohorts of children born 2021-2023 and their parents for discovery and interventional research. GenV is designed to address physical, mental, and social issues experienced during childhood, as well as the antecedents of a wide range of diseases of ageing. It will generate translatable evidence—including prediction, prevention, treatments, and services—to improve future well-being and reduce future disease burden. GenV’s ‘building blocks’ comprise consent, biosamples, linkage to administrative and service/clinical data, GenV-collected data, a capability for integrated studies, and a platform designed to provide value to its consumers. Inclusivity and Open Science are core values.

Recruited number of:
39685 children / 39197 mothers / 21487 fathers / 14 grand parents / 247 other family members

Approximate proportion of source population included
26

Source population
Region-based
Period of enrollment
Start: 2021-10-04, End: 0000-00-00

Enrollment period
At birth to

Enrollment criteria, please specify
Inclusion Criteria (Children): • Birth date between 4th October 2021 and 3rd October 2023 • Live at the time of recruitment • Residing in Victoria at the time of recruitment • Has a legally acceptable representative capable of understanding the informed consent document and providing consent on the child's behalf, who provides a signed and dated informed consent form (e.g. a parent/guardian). Inclusion Criteria (Adults): • Be a parent or guardian of a child who meets the eligibility criteria above • Provide a signed and dated informed consent form or have a legally acceptable representative capable of understanding the informed consent document and providing consent on the participant's behalf.

Exclusion criteria, please specify
• Babies who are deceased at the time of recruitment (i.e. still born or died after birth) and their parents/guardians • Families unable to provide informed consent in any of the languages available

Planned age of children at end of follow-up
Life-long / unrestricted

Questionnaire or registry data and biological samples

General information	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Home address	X	X
School address

Birth outcomes
Birth weight	X
Birth length	X
Gestational age at birth	X
Apgar score	X
Congenital malformations	X
Stillbirth (>= 22 weeks)
Child’s sex	X
Head circumference	X
Biparietal diameter

Child exposures	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Breast feeding	X	X
Diet	X	X
Dietary supplements	X	X
Childcare attendance
Active smoking
Passive smoking
Alcohol consumption
Physical activity	X	X
Substance use
Medicine intake	X	X
Vaccinations
Psychological distress (e.g. bullying)
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Child development and health	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Anthropometry
Weight	X	X
Height	X	X
Head circumference	X	X
Abdominal circumference
Arm circumference
Wrist circumference
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
Cardiac ultrasound
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan results
Skin folds
Bio impedence
Oscilometry
Spirometry
Skin prick test
Bronchial challenge test
Reversibility test
Dental observations
Mental and neurological development
Cognitive function
School performance
Language		X
ADHD
Autism
Sleep disturbances	X
Mental health	X
Respiratory health
Asthma	X	X
Allergy	X	X
Allergic rhinitis
Eczema	X	X
Respiratory tract infections	X	X
Senses
Vision	X	X
Hearing	X	X
Musculo-skeletal health
Back pain
Neck pain
Growing pains
Sexual maturation
Tanner stage
Pubertal development stage
Age at menarche
Age at voice change
2D/4D digit ratio
Nocturnal ejaculation
Acne
Other health outcomes
Cancer
Diabetes
Congenital anomalies	X	X
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Child biological samples	---------- Child age (years) at sampling ----------
	At birth	0	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Teeth
Nails
Saliva		X
Purified DNA
Purified RNA
Red blood cells
Umbilical cord blood/tissue
Blood smear
Faeces/meconium		X
Exhaled breathe condensate
Sputum induction
Placenta

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education			X
Income
Employment status
Job title
Single parenthood			X
Home address			X	X
Work address

Maternal characteristics related to the index pregnancy/child
Age at birth	X
Ethnicity	X
Country of birth	X
Planned pregnancy
Time to pregnancy
Fertility treatment	X
Prior spontaneous abortion (<22w)
Prior births
Ultrasound measurements
Doppler measurements
Preeclampsia
Gestational diabetes
Gestational hypertension
Gestational duration	X
Mode of delivery	X
Prenatal diagnostics
Medical termination of pregnancy

Maternal Exposures	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Diet
Dietary supplements		X	X	X
Active smoking
Passive smoking
Alcohol consumption
Physical activity
Substance use
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Maternal health	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Anthropometry
Weight	X			X	X
Height					X
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence
Mental and neurological development
Mental health	X	X	X	X	X
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma					X
Allergy					X
Musculo‐skeletal disease
Back pain					X
Neck pain					X
Arthritis
Other health outcomes
Cancer					X
Diabetes					X
Cardio‐vascular disease					X
Family history of chronic disease
Infectious disease					X
Fever					X
Autoimmune disease
Urinary symptoms					X
Sexual problems					X
Sleep disturbance					X
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Maternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Breast milk					X
Whole blood
Serum		X	X	X
Plasma		X	X	X
Buffy coat
Urine
Hair
Nails
Saliva					X
Purified DNA
Purified RNA
Red blood cells
Faeces

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education			X
Income
Employment status
Job title
Single parenthood			X
Home address			X	X
Work address

Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birth	X
Ethnicity	X
Country of birth	X

Paternal exposures	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Diet
Dietary supplements
Active smoking
Passive smoking
Alcohol consumption
Physical activity
Substance use
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Paternal health	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Anthropometry
Weight			X
Height			X
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental health			X
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma			X
Allergy			X
Musculo‐skeletal disease
Back pain			X
Neck pain			X
Arthritis
Other health outcomes
Cancer			X
Diabetes			X
Cardio‐vascular disease			X
Family history of chronic disease
Infectious disease			X
Fever			X
Autoimmune disease
Urinary symptoms			X
Sexual problems			X
Sleep disturbance			X
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Paternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Semen
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva			X
Purified DNA
Purified RNA
Red blood cells
Faeces

Comments and ideas

Comments and ideas
Generation Victoria (GenV) is a longitudinal, population-based study of Victorian children and their parents that will bring together data on a wide range of conditions, exposures and outcomes. GenV blends study-collected, study-enhanced and linked data. It will be multi-purpose, supporting observational, interventional, health services and policy research within the same cohort. It is designed to address physical, mental and social issues experienced during childhood, as well as the antecedents of a wide range of diseases of ageing. It seeks to generate translatable evidence (prediction, prevention, treatments, services) to improve future wellbeing and reduce the future disease burden of children and adults. The GenV Cohort 2020s is open to all babies born over a two-year period, and their parents, residing in the state of Victoria Australia. The GenV Cohort 2020s is preceded by an Advance Cohort of babies born between 5 Dec 2020 and 3 October 2021, and their parents. This comprises all families recruited at GenV's Vanguard hospital (Joan Kirner Women's and Children's) and at birthing hospitals throughout Victoria as GenV scaled up to commence recruiting for the GenV Cohort 2020s. The Advance Cohort have ongoing and full participation in GenV for their lifetime unless they withdraw but may have less complete data and biosamples. In addition to the biological samples listed above, GenV also access samples from the newborn screening Guthrie blood cards and maternal third trimester vaginal/anal swabs (excess Group B Streptococcus clinical pathology test).