Identification

• Cohort, name
  Amsterdam Born Children and their Development
  
  Cohort, abbreviation
  ABCD
  
  Cohort, country
  Netherlands (Nederland)
  
  Cohort, website
  http://www.abcd-studie.nl
  
  Cohort, facebook-site
  http://www.facebook.com/ABCDstudie/
  
  Key reference
  van Eijsden M, Vrijkotte TG, Gemke RJ, van der Wal MF. Cohort profile: the Amsterdam Born Children and their Development (ABCD) study. Int J Epidemiol. 2011 Oct;40(5):1176-86.
  
  Date of filling in this questionnaire:
  2021-04-15
  
  
• Principal investigator(s), name
  Tanja G.M. Vrijkotte
  
  Principal investigator(s), e-mail address
  t.vrijkotte@amc.uva.nl
  
  Principal investigator(s), institution
  Department of Public and Occupational Health, Amsterdam Public Health Research Institute, Amsterdam UMC, Location Academic Me
  
  Contact person(s), name
  Noekie van Lieshout
  
  Contact person(s), e-mail address
  abcd@amsterdamumc.nl
  
  Contact person(s), institution address
  Academic Medical Centre/Department of Public Health/University of Amsterdam
  
  

Basic description

• Main aim of cohort
  Prospective cohort study on the association between lifestyle, psychosocial conditions, and nutritional status during pregnancy, and the childs health at birth (birth weight, pregnancy duration, perinatal mortality) and in later life (growth, physical development, behhaviour and cognitive functioning).
  
  Recruited number of:
  6161 children / 8266 mothers / 2270 fathers / 0 grand parents / 0 other family members
  
  Approximate proportion of source population included
  67
  
  Source population
  Region-based
  
  
• Period of enrollment
  Start: 2003-01-01, End: 2004-03-01
  
  Enrollment period
  Pregnancy, week 14 to 18
  
  Enrollment criteria, please specify
  Place of residence: Amsterdam
  
  Planned age of children at end of follow-up
  25 years

Questionnaire or registry data and biological samples

• Children
• Mothers
• Fathers

General information	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Home address	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
School address	X					X						X

Birth outcomes
Birth weight	X
Birth length
Gestational age at birth	X
Apgar score	X
Congenital malformations	X
Stillbirth (>= 22 weeks)	X
Child’s sex	X
Head circumference	X
Biparietal diameter

Child exposures	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Breast feeding	X	X	X
Diet	X					X						X				X
Dietary supplements	X	X	X
Childcare attendance	X
Active smoking												X				X
Passive smoking	X					X						X				X
Alcohol consumption												X				X
Physical activity						X		X				X				X
Substance use												X				X
Medicine intake	X					X						X				X
Vaccinations
Psychological distress (e.g. bullying)						X						X				X
Air pollution	X					X
Access to green spaces	X					X			X			X
Built environment	X					X			X			X
Noise	X					X			X			X
Radiation, electromagnetic fields								X				X
Water contamination
Pets								X
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Child development and health	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Anthropometry
Weight	X	X	X	X	X	X		X			X	X				X
Height	X	X	X	X	X	X		X			X	X				X
Head circumference	X	X
Abdominal circumference						X						X
Arm circumference						X						X
Wrist circumference
Waist circumference						X						X
Clinical examinations
Blood pressure						X						X
Carotida intima media thickness												X
Pulse wave velocity
Cardiac ultrasound
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan results
Skin folds
Bio impedence						X						X
Oscilometry
Spirometry
Skin prick test
Bronchial challenge test
Reversibility test
Dental observations
Mental and neurological development
Cognitive function						X						X				X
School performance						X						X
Language						X
ADHD						X						X				X
Autism						X						X				X
Sleep disturbances						X		X				X				X
Mental health	X					X						X				X
Respiratory health
Asthma						X		X				X				X
Allergy								X								X
Allergic rhinitis
Eczema								X								X
Respiratory tract infections
Senses
Vision
Hearing
Musculo-skeletal health
Back pain
Neck pain
Growing pains
Sexual maturation
Tanner stage												X				X
Pubertal development stage												X				X
Age at menarche												X				X
Age at voice change
2D/4D digit ratio
Nocturnal ejaculation
Acne												X				X
Other health outcomes
Cancer	X					X						X				X
Diabetes	X					X						X				X
Congenital anomalies	X					X						X				X
Biomarkers of health
Nephrology (e.g. creatinine, albumin)						X
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)						X						X
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)						X

Child biological samples	---------- Child age (years) at sampling ----------
	At birth	0	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Whole blood							X						X
Serum
Plasma
Buffy coat
Urine
Hair
Teeth
Nails
Saliva													X
Purified DNA							X
Purified RNA
Red blood cells
Umbilical cord blood/tissue
Blood smear
Faeces/meconium
Exhaled breathe condensate
Sputum induction
Placenta

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education		X						X						X				X
Income								X						X				X
Employment status		X
Job title		X
Single parenthood		X						X						X				X
Home address		X						X						X				X
Work address

Maternal characteristics related to the index pregnancy/child
Age at birth	X
Ethnicity	X
Country of birth	X
Planned pregnancy	X
Time to pregnancy	X
Fertility treatment	X
Prior spontaneous abortion (<22w)	X
Prior births	X
Ultrasound measurements
Doppler measurements
Preeclampsia	X
Gestational diabetes	X
Gestational hypertension	X
Gestational duration	X
Mode of delivery	X
Prenatal diagnostics	X
Medical termination of pregnancy	X

Maternal Exposures	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Diet	X	X	X	X
Dietary supplements	X	X	X	X
Active smoking	X	X	X	X	X
Passive smoking	X	X	X	X	X
Alcohol consumption	X	X	X	X	X
Physical activity	X	X	X	X
Substance use	X	X	X	X	X
Medicine intake	X	X	X	X	X
Coffee drinking	X	X	X	X
Psychological distress (e.g. life-events, health behaviors, perceived stress)	X	X	X	X	X
Occupational exposures	X	X	X	X	X
Heavy lifts	X	X	X	X
Work hours		X	X	X
Air pollution		X			X
Access to green spaces		X			X
Built environment		X			X
Noise		X			X
Radiation, electromagnetic fields
Water contamination					X
Binge drinking	X	X	X	X	X
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Maternal health	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Anthropometry
Weight	X	X			X
Height	X	X			X
Waist circumference
Clinical examinations
Blood pressure	X	X	X	X
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence
Mental and neurological development
Mental health	X	X			X
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma					X
Allergy					X
Musculo‐skeletal disease	X	X	X	X	X
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer	X	X	X	X	X
Diabetes	X	X	X	X	X
Cardio‐vascular disease	X	X	X	X	X
Family history of chronic disease					X
Infectious disease	X	X	X	X	X
Fever
Autoimmune disease	X	X	X	X	X
Urinary symptoms
Sexual problems
Sleep disturbance		X			X
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones		X
Inflammatory markers (e.g. C-reactive protein cytokines)		X
Immunologic markers (e.g. immunoglobulines)
Cortisol		X
Vitamines and micronutrients		X
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Maternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Breast milk
Whole blood
Serum		X
Plasma		X
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education	X	X												X				X
Income														X				X
Employment status
Job title
Single parenthood														X				X
Home address
Work address

Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birth	X
Ethnicity	X
Country of birth	X

Paternal exposures	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Diet			X
Dietary supplements
Active smoking			X
Passive smoking			X
Alcohol consumption			X
Physical activity			X
Substance use			X
Medicine intake			X
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)			X
Occupational exposures			X
Heavy lifts
Work hours			X
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Paternal health	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Anthropometry
Weight			X
Height			X
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental health			X
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer
Diabetes			X
Cardio‐vascular disease			X
Family history of chronic disease			X
Infectious disease
Fever
Autoimmune disease
Urinary symptoms
Sexual problems
Sleep disturbance			X
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Paternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Semen
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces

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