Identification

• Cohort, name
  Polish Mother and Child Cohort Study
  
  Cohort, abbreviation
  REPRO_PL
  
  Cohort, country
  Poland (Polska)
  
  Cohort, website
  http://www.repropl.com/
  
  Key reference
  Polanska K, Hanke W, Gromadzinska J, Ligocka D, Gulczynska E, Sobala W, Wasowicz W. Polish mother and child cohort study — defining the problem, the aim of the study and methodological assumptions. International Journal of Occupational Medicine and Environmental Health 2009;22(4):383–391
  
  Date of filling in this questionnaire:
  2017-08-03
  
  
• Principal investigator(s), name
  Wojciech Hanke
  
  Principal investigator(s), e-mail address
  wojciech.hanke@imp.lodz.pl
  
  Principal investigator(s), institution
  Nofer Institute of Occupational Medicine, 91-348 Lodz, Poland, Teresy 8 ST.
  
  Contact person(s), name
  Kinga Polanska
  
  Contact person(s), e-mail address
  kinga.polanska@imp.lodz.pl
  
  Contact person(s), institution address
  Nofer Institute of Occupational Medicine, 91-348 Lodz, Poland, Teresy 8 St.
  
  

Basic description

• Main aim of cohort
  The aim of the study is to evaluate the impact of exposure to different environmental factors during pregnancy and after birth on pregnancy outcome and children’s health. Specific research hypotheses refer to the role of heavy metals, exposure to polycyclic aromatic hydrocar­bons, and environmental tobacco smoke in the aetiology of intrauterine growth retardation, preterm delivery and the risk of respiratory diseases, allergy and poor mental and physical development. It is also intended to explain the role of oxidative stress and nutritional status of the pregnant women. The impact of occupational exposures and stressful situations on pregnancy outcome will be evaluated from question­naire data.
  
  Recruited number of:
  1800 children / 1800 mothers / 0 fathers / 0 grand parents / 0 other family members
  
  Approximate proportion of source population included
  0
  
  Source population
  Nation-based
  
  
• Period of enrollment
  Start: 2007-01-01, End: 2011-12-31
  
  Enrollment period
  Pregnancy, week 8 to 12
  
  Enrollment criteria, please specify
  1) women between 8–12 weeks of single pregnancy 2) pregnancy not assisted with reproductive technology 3) pregnancy not expected to be finished as spontaneous abortion
  
  Exclusion criteria, please specify
  1) women with the serious chronic diseases specified in study protocol such as diabetes, hypertension, nephropathy, epilepsy and cancer 2) suspicion of serious child malformations
  
  Planned age of children at end of follow-up
  life-long (current stage - 7-8 years of age) years

Questionnaire or registry data and biological samples

• Children
• Mothers
• Fathers

General information	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Home address	X	X	X					X
School address

Birth outcomes
Birth weight	X
Birth length	X
Gestational age at birth	X
Apgar score	X
Congenital malformations	X
Stillbirth (>= 22 weeks)	X
Child’s sex	X
Head circumference	X
Biparietal diameter	X

Child exposures	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Breast feeding	X	X	X
Diet	X	X	X					X
Dietary supplements	X	X	X					X
Childcare attendance	X	X	X
Active smoking
Passive smoking	X	X	X					X
Alcohol consumption
Physical activity	X	X	X					X
Substance use
Medicine intake	X	X	X					X
Vaccinations	X	X	X					X
Psychological distress (e.g. bullying)								X
Air pollution	X	X	X					X
Access to green spaces								X
Built environment								X
Noise	X	X	X					X
Radiation, electromagnetic fields								X
Water contamination
Pets	X	X	X					X
Farm animal exposure	X	X	X					X
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A								X
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates			X					X
Cotinine		X	X					X

Child development and health	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Anthropometry
Weight	X	X	X					X
Height	X	X	X					X
Head circumference	X	X	X
Abdominal circumference		X	X					X
Arm circumference		X	X					X
Wrist circumference
Waist circumference								X
Clinical examinations
Blood pressure								X
Carotida intima media thickness
Pulse wave velocity
Cardiac ultrasound
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan results
Skin folds
Bio impedence
Oscilometry
Spirometry								X
Skin prick test								X
Bronchial challenge test
Reversibility test
Dental observations								X
Mental and neurological development
Cognitive function		X	X					X
School performance
Language		X	X					X
ADHD								X
Autism
Sleep disturbances
Mental health	X	X	X					X
Respiratory health
Asthma								X
Allergy	X	X	X					X
Allergic rhinitis	X	X	X					X
Eczema	X	X	X					X
Respiratory tract infections	X	X	X					X
Senses
Vision								X
Hearing								X
Musculo-skeletal health
Back pain								X
Neck pain								X
Growing pains
Sexual maturation
Tanner stage
Pubertal development stage
Age at menarche
Age at voice change
2D/4D digit ratio
Nocturnal ejaculation
Acne
Other health outcomes
Cancer	X	X	X					X
Diabetes	X	X	X					X
Congenital anomalies								X
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Child biological samples	---------- Child age (years) at sampling ----------
	At birth	0	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Whole blood	X
Serum
Plasma	X
Buffy coat	X
Urine			X	X					X
Hair
Teeth
Nails
Saliva			X	X					X
Purified DNA
Purified RNA
Red blood cells
Umbilical cord blood/tissue	X
Blood smear
Faeces/meconium
Exhaled breathe condensate
Sputum induction
Placenta

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education		X		X	X					X
Income		X		X	X					X
Employment status		X		X	X					X
Job title		X		X	X					X
Single parenthood		X		X	X					X
Home address		X		X	X					X
Work address

Maternal characteristics related to the index pregnancy/child
Age at birth	X
Ethnicity	X
Country of birth	X
Planned pregnancy	X
Time to pregnancy
Fertility treatment
Prior spontaneous abortion (<22w)	X
Prior births	X
Ultrasound measurements	X
Doppler measurements
Preeclampsia	X
Gestational diabetes	X
Gestational hypertension	X
Gestational duration	X
Mode of delivery	X
Prenatal diagnostics	X
Medical termination of pregnancy	X

Maternal Exposures	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Diet		X	X	X
Dietary supplements	X	X	X	X
Active smoking	X	X	X	X	X
Passive smoking	X	X	X	X	X
Alcohol consumption			X
Physical activity		X	X	X
Substance use			X
Medicine intake	X	X	X	X
Coffee drinking			X
Psychological distress (e.g. life-events, health behaviors, perceived stress)			X	X
Occupational exposures	X	X	X	X	X
Heavy lifts		X	X	X
Work hours		X	X	X
Air pollution		X	X	X	X
Access to green spaces
Built environment
Noise		X
Radiation, electromagnetic fields					X
Water contamination
Binge drinking			X
Pets	X	X	X	X	X
Farm animal exposure	X	X	X	X	X
Biomarkers of exposure
Mercury				X
Lead			X	X
Cadmium			X	X
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates				X
Cotinine		X	X	X	X

Maternal health	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Anthropometry
Weight	X	X	X	X
Height		X
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma					X
Allergy					X
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer		X	X	X
Diabetes		X	X	X
Cardio‐vascular disease		X	X	X
Family history of chronic disease
Infectious disease		X	X	X
Fever		X	X	X
Autoimmune disease		X	X	X
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients		X	X	X
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation				X
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Maternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Breast milk					X
Whole blood			X
Serum
Plasma		X	X	X
Buffy coat		X	X	X
Urine			X	X
Hair				X
Nails
Saliva		X	X	X	X
Purified DNA		X	X	X
Purified RNA
Red blood cells
Faeces

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education				X	X					X
Income				X	X					X
Employment status										X
Job title
Single parenthood										X
Home address				X	X					X
Work address

Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birth	X
Ethnicity	X
Country of birth	X

Paternal exposures	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Diet
Dietary supplements
Active smoking		X	X
Passive smoking
Alcohol consumption
Physical activity
Substance use
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures
Heavy lifts
Work hours
Air pollution		X	X
Access to green spaces
Built environment
Noise		X
Radiation, electromagnetic fields			X
Water contamination
Binge drinking
Pets	X	X	X
Farm animal exposure	X	X	X
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Paternal health	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Anthropometry
Weight
Height
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma			X
Allergy			X
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer
Diabetes
Cardio‐vascular disease
Family history of chronic disease
Infectious disease
Fever
Autoimmune disease
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Paternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Semen
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces

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