Identification

• Cohort, name
  Generation R
  
  Cohort, abbreviation
  
  
  Cohort, country
  Netherlands (Nederland)
  
  Cohort, website
  http://www.generationr.nl
  
  Cohort, facebook-site
  http://nl-nl.facebook.com/pages/Generation-R/143785198989549
  
  Key reference
  Jaddoe VW, van Duijn CM, van der Heijden AJ, Mackenbach JP, Moll HA, Steegers EA, Tiemeier H, Uitterlinden AG, Verhulst FC, Hofman A. The Generation R Study: design and cohort update 2010. Eur J Epidemiol. 2010 Nov;25(11):823-41.
  
  Date of filling in this questionnaire:
  2011-10-07
  
  
• Principal investigator(s), name
  Vincent Jaddoe
  
  Principal investigator(s), e-mail address
  v.jaddoe@erasmusmc.nl
  
  Principal investigator(s), institution
  Erasmus Medical Center Rotterdam, Generation R (Room AE006) PO Box 2040, 3000 CA, Rotterdam, the Netherlands
  
  Contact person(s), name
  Frank Pierik , Edith van den Hooven
  
  Contact person(s), e-mail address
  frank.pierik@tno.nl , e.vandenhooven@erasmusmc.nl
  
  Contact person(s), institution address
  Erasmus Medical Center Rotterdam, Generation R (Room AE006) PO Box 2040, 3000 CA, Rotterdam, the Netherlands
  
  

Basic description

• Main aim of cohort
  Identification of early critical periods and causal pathways for growth, development and health
  
  Recruited number of:
  10000 children / 97780 mothers / 6500 fathers / 0 grand parents / 0 other family members
  
  Approximate proportion of source population included
  65
  
  Source population
  Region-based
  
  
• Period of enrollment
  Start: 2002-01-21, End: 2006-02-01
  
  Enrollment period
  Pregnancy, week 18 to birth
  
  Planned age of children at end of follow-up
  Life-long / unrestricted

Questionnaire or registry data and biological samples

• Children
• Mothers
• Fathers

General information	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Home address
School address

Birth outcomes
Birth weight	X
Birth length	X
Gestational age at birth	X
Apgar score	X
Congenital malformations	X
Stillbirth (>= 22 weeks)	X
Child’s sex
Head circumference
Biparietal diameter

Child exposures	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Breast feeding	X	X	X
Diet	X	X	X					X
Dietary supplements
Childcare attendance	X	X	X	X	X	X
Active smoking
Passive smoking			X	X	X	X
Alcohol consumption
Physical activity
Substance use
Medicine intake
Vaccinations
Psychological distress (e.g. bullying)
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Child development and health	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Anthropometry
Weight
Height
Head circumference	X	X				X				X
Abdominal circumference
Arm circumference
Wrist circumference
Waist circumference
Clinical examinations
Blood pressure			X			X				X
Carotida intima media thickness
Pulse wave velocity
Cardiac ultrasound	X		X			X
Renal ultrasound	X		X			X
Brain MRI								X		X
Other MRI
DEXA‐scan results	X		X			X				X
Skin folds
Bio impedence
Oscilometry
Spirometry
Skin prick test
Bronchial challenge test
Reversibility test
Dental observations
Mental and neurological development
Cognitive function	X	X	X			X				X
School performance
Language		X
ADHD
Autism
Sleep disturbances
Mental health
Respiratory health
Asthma
Allergy
Allergic rhinitis
Eczema
Respiratory tract infections
Senses
Vision
Hearing
Musculo-skeletal health
Back pain
Neck pain
Growing pains
Sexual maturation
Tanner stage
Pubertal development stage
Age at menarche
Age at voice change
2D/4D digit ratio
Nocturnal ejaculation
Acne
Other health outcomes
Cancer
Diabetes
Congenital anomalies
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Child biological samples	---------- Child age (years) at sampling ----------
	At birth	0	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Whole blood	X						X
Serum	X						X
Plasma
Buffy coat
Urine							X
Hair							X
Teeth
Nails
Saliva							X
Purified DNA	X						X
Purified RNA
Red blood cells
Umbilical cord blood/tissue	X
Blood smear
Faeces/meconium
Exhaled breathe condensate
Sputum induction
Placenta

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education		X
Income		X
Employment status
Job title
Single parenthood		X
Home address
Work address

Maternal characteristics related to the index pregnancy/child
Age at birth	X
Ethnicity	X
Country of birth
Planned pregnancy	X
Time to pregnancy	X
Fertility treatment	X
Prior spontaneous abortion (<22w)	X
Prior births	X
Ultrasound measurements
Doppler measurements
Preeclampsia	X
Gestational diabetes
Gestational hypertension
Gestational duration	X
Mode of delivery	X
Prenatal diagnostics	X
Medical termination of pregnancy	X

Maternal Exposures	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Diet		X
Dietary supplements		X
Active smoking		X	X	X
Passive smoking	X	X	X	X
Alcohol consumption		X	X	X
Physical activity		X
Substance use		X	X	X
Medicine intake		X	X	X
Coffee drinking		X	X
Psychological distress (e.g. life-events, health behaviors, perceived stress)			X
Occupational exposures				X
Heavy lifts		X
Work hours
Air pollution		X	X	X	X
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination		X
Binge drinking		X	X	X
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Maternal health	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Anthropometry
Weight
Height
Waist circumference
Clinical examinations
Blood pressure		X	X	X	X
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence
Mental and neurological development
Mental health		X
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal disease		X
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer		X
Diabetes		X			X
Cardio‐vascular disease
Family history of chronic disease
Infectious disease		X
Fever		X
Autoimmune disease		X
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Maternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Breast milk
Whole blood
Serum		X	X		X
Plasma
Buffy coat
Urine		X	X		X
Hair
Nails
Saliva
Purified DNA		X	X
Purified RNA
Red blood cells
Faeces

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education		X
Income		X
Employment status
Job title
Single parenthood
Home address
Work address

Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birth
Ethnicity
Country of birth

Paternal exposures	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Diet
Dietary supplements
Active smoking		X
Passive smoking		X
Alcohol consumption		X
Physical activity
Substance use		X
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures		X
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Paternal health	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Anthropometry
Weight
Height
Waist circumference
Clinical examinations
Blood pressure		X
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental health		X
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal disease		X
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer		X
Diabetes		X
Cardio‐vascular disease		X
Family history of chronic disease
Infectious disease		X
Fever
Autoimmune disease		X
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Paternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Semen
Whole blood		X
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA		X
Purified RNA
Red blood cells
Faeces

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