Identification

• Cohort, name
  Krakow Cohort
  
  Cohort, abbreviation
  
  
  Cohort, country
  Poland (Polska)
  
  Key reference
  Jedrychowski W, Whyatt RM, Camann DE, Bawle UV, Peki K, Spengler JD, Dumyahn TS, Penar A, Perera FF. Effect of prenatal PAH exposure on birth outcomes and neurocognitive development in a cohort of newborns in Poland. Study design and preliminary ambient data. Int J Occup Med Environ Health 16:21-29.
  
  Date of filling in this questionnaire:
  2011-10-11
  
  
• Principal investigator(s), name
  Frederica Perera; Agnieszka Pac
  
  Principal investigator(s), e-mail address
  agnieszka.pac@uj.edu.pl
  
  Principal investigator(s), institution
  Jagiellonian University Medical College
  
  Contact person(s), name
  Renata Majewska
  
  Contact person(s), e-mail address
  rmajewska@cm-uj.krakow.pl
  
  

Basic description

• Recruited number of:
  505 children / 528 mothers / 0 fathers / 0 grand parents / 0 other family members
  
  Approximate proportion of source population included
  0
  
  Source population
  Region-based
  
  
• Period of enrollment
  Start: 2000-00-00, End: 2003-00-00
  
  Enrollment period
  Pregnancy, week 8 to 13
  
  Enrollment criteria, please specify
  Nonsmoking women, permanent residents of Krakow, women who have resided for the past year in teh area of the high (the Srodmiescie district) or low PAH levels, - singleton pregnancies -between the ages of 18 and 35 years
  
  Exclusion criteria, please specify
  - chronic diseases (diabetes and hypertension) - history of using illicit drugs - at risk of occupational exposures to PAH or other developmental toxicants (coke oven, chemical or rubber workers)
  
  Planned age of children at end of follow-up
  17 years

Questionnaire or registry data and biological samples

• Children
• Mothers
• Fathers

General information	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Home address	X	X	X	X	X	X	X	X	X	X			X	X	X	X
School address

Birth outcomes
Birth weight	X
Birth length	X
Gestational age at birth	X
Apgar score	X
Congenital malformations	X
Stillbirth (>= 22 weeks)
Child’s sex	X
Head circumference	X
Biparietal diameter

Child exposures	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Breast feeding	X	X	X	X
Diet	X	X	X	X	X	X	X	X	X	X			X	X	X	X
Dietary supplements
Childcare attendance
Active smoking													X	X	X	X
Passive smoking	X	X	X	X	X	X	X	X	X	X			X	X	X	X
Alcohol consumption													X	X	X	X
Physical activity										X
Substance use													X	X	X	X
Medicine intake					X	X	X	X	X	X
Vaccinations	X	X	X	X
Psychological distress (e.g. bullying)
Air pollution				X			X
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Pets				X	X	X	X	X	X	X			X	X	X	X
Farm animal exposure
Biomarkers of exposure
Mercury						X
Lead						X
Cadmium						X
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Child development and health	---------- Child age (years) at assessment ----------
	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Anthropometry
Weight				X	X	X	X	X	X	X			X	X	X	X
Height				X	X	X	X	X	X	X			X	X	X	X
Head circumference				X
Abdominal circumference
Arm circumference
Wrist circumference
Waist circumference
Clinical examinations
Blood pressure									X	X
Carotida intima media thickness
Pulse wave velocity
Cardiac ultrasound
Renal ultrasound
Brain MRI
Other MRI
DEXA‐scan results
Skin folds
Bio impedence										X
Oscilometry
Spirometry					X	X	X	X	X	X
Skin prick test						X			X
Bronchial challenge test
Reversibility test
Dental observations
Mental and neurological development
Cognitive function				X		X	X	X	X	X
School performance
Language
ADHD
Autism
Sleep disturbances
Mental health
Respiratory health
Asthma						X	X	X	X	X			X	X	X	X
Allergy	X	X	X	X	X	X	X	X	X	X			X	X	X	X
Allergic rhinitis				X	X	X	X	X	X	X			X	X	X	X
Eczema	X	X	X	X	X	X	X	X	X	X			X	X	X	X
Respiratory tract infections	X	X	X	X	X	X	X	X	X	X			X	X	X	X
Senses
Vision
Hearing
Musculo-skeletal health
Back pain
Neck pain
Growing pains
Sexual maturation
Tanner stage
Pubertal development stage
Age at menarche
Age at voice change
2D/4D digit ratio
Nocturnal ejaculation
Acne
Other health outcomes
Cancer
Diabetes
Congenital anomalies
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Child biological samples	---------- Child age (years) at sampling ----------
	At birth	0	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	>18
Whole blood							X
Serum
Plasma
Buffy coat
Urine					X			X	X	X
Hair
Teeth
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Umbilical cord blood/tissue	X
Blood smear
Faeces/meconium
Exhaled breathe condensate
Sputum induction
Placenta

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education		X
Income
Employment status
Job title
Single parenthood		X
Home address
Work address

Maternal characteristics related to the index pregnancy/child
Age at birth	X
Ethnicity
Country of birth
Planned pregnancy
Time to pregnancy
Fertility treatment
Prior spontaneous abortion (<22w)
Prior births
Ultrasound measurements
Doppler measurements
Preeclampsia
Gestational diabetes
Gestational hypertension
Gestational duration
Mode of delivery	X
Prenatal diagnostics
Medical termination of pregnancy

Maternal Exposures	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Diet			X
Dietary supplements		X	X	X
Active smoking	X				X
Passive smoking	X	X	X	X	X
Alcohol consumption	X
Physical activity
Substance use	X
Medicine intake		X	X	X	X
Coffee drinking	X	X	X	X
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures	X
Heavy lifts
Work hours
Air pollution	X		X
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination			X	X
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Maternal health	---------- Timing of assessment ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Anthropometry
Weight	X		X
Height	X		X
Waist circumference
Clinical examinations
Blood pressure					X
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bioimpedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer
Diabetes
Cardio‐vascular disease
Family history of chronic disease
Infectious disease		X	X	X
Fever
Autoimmune disease
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Maternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post pregnancy
Breast milk
Whole blood					X
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces

General information
	Pre-pregnancy	During pregnancy	<1	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Education
Income
Employment status
Job title
Single parenthood
Home address
Work address

Paternal characteristics related to the index pregnancy/child
Fertility treatment
Age at child's birth
Ethnicity
Country of birth

Paternal exposures	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Diet
Dietary supplements
Active smoking
Passive smoking
Alcohol consumption
Physical activity
Substance use
Medicine intake
Coffee drinking
Psychological distress (e.g. life-events, health behaviors, perceived stress)
Occupational exposures
Heavy lifts
Work hours
Air pollution
Access to green spaces
Built environment
Noise
Radiation, electromagnetic fields
Water contamination
Binge drinking
Pets
Farm animal exposure
Biomarkers of exposure
Mercury
Lead
Cadmium
Arsenic
Other metals
Polychlorinated biphenyl esters
Dicloro difenil tricloroetano
Hexachlorobenzene
Brominated flame retardants
Perflouralkyl compounds
Bisphenol A
Other bisphenols
Parabens
Benzophenones
Triclosan
Phthalates
Cotinine

Paternal health	---------- Timing of assessment ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Anthropometry
Weight
Height
Waist circumference
Clinical examinations
Blood pressure
Carotida intima media thickness
Pulse wave velocity
DEXA scans
Bio impedence
Mental and neurological development
Mental health
Cognitive function (e.g. intelligence quotient)
Respiratory health
Asthma
Allergy
Musculo‐skeletal disease
Back pain
Neck pain
Arthritis
Other health outcomes
Cancer
Diabetes
Cardio‐vascular disease
Family history of chronic disease
Infectious disease
Fever
Autoimmune disease
Urinary symptoms
Sexual problems
Sleep disturbance
Biomarkers of health
Nephrology (e.g. creatinine, albumin)
Thyroid hormones
Inflammatory markers (e.g. C-reactive protein cytokines)
Immunologic markers (e.g. immunoglobulines)
Cortisol
Vitamines and micronutrients
Gonadal axis hormones (e.g. testosterone, estradiol)
Metabolism (e.g. cholesterol, LDL, HDL, insulin, triglycerides)
Metabolomics
DNA methylation
Transcriptomics (mRNA, miRNA)
Genome-wide association study (GWAS)

Paternal biological samples	---------- Timing of sampling ----------
	Pre-pregnancy	During pregnancy	Post pregnancy
Semen
Whole blood
Serum
Plasma
Buffy coat
Urine
Hair
Nails
Saliva
Purified DNA
Purified RNA
Red blood cells
Faeces

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